Prenatal hypoxia and placental oxidative stress: linkages to developmental origins of cardiovascular disease.

Autor:	Aljunaidy MM; Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada.; Department of Physiology, University of Alberta, Edmonton, Canada; and.; Women and Children's Health Research Institute and the Cardiovascular Research Centre, Edmonton, Canada., Morton JS; Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada.; Women and Children's Health Research Institute and the Cardiovascular Research Centre, Edmonton, Canada., Cooke CM; Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada.; Women and Children's Health Research Institute and the Cardiovascular Research Centre, Edmonton, Canada., Davidge ST; Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada; sandra.davidge@ualberta.ca.; Department of Physiology, University of Alberta, Edmonton, Canada; and.; Women and Children's Health Research Institute and the Cardiovascular Research Centre, Edmonton, Canada.
Jazyk:	angličtina
Zdroj:	American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2017 Oct 01; Vol. 313 (4), pp. R395-R399. Date of Electronic Publication: 2017 Aug 09.
DOI:	10.1152/ajpregu.00245.2017
Abstrakt:	Intrauterine growth restriction (IUGR, a pregnancy complication where the fetus does not reach its genetic growth potential) is a leading cause of fetal morbidity and mortality with a significant impact on population health. IUGR is associated with gestational hypoxia; which can lead to placental oxidative stress and fetal programming of cardiovascular disease. Mitochondria are a major source of placental oxidative stress and may provide a therapeutic target to mitigate the detrimental effects of placental oxidative stress on pregnancy outcomes. A nanoparticle-mediated delivery of a mitochondrial antioxidant to the placenta is a potential novel approach that may avoid unwanted off-target effects on the developing offspring. (Copyright © 2017 the American Physiological Society.)
Databáze:	MEDLINE
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