Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity.

Autor: Neumann DP; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, 5000, Australia., Goodall GJ; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, 5000, Australia; Discipline of Medicine, The University of Adelaide, Adelaide, SA 5005, Australia; School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA 5005, Australia., Gregory PA; Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, 5000, Australia; Discipline of Medicine, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: philip.gregory@unisa.edu.au.
Jazyk: angličtina
Zdroj: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2018 Mar; Vol. 75, pp. 50-60. Date of Electronic Publication: 2017 Aug 05.
DOI: 10.1016/j.semcdb.2017.08.008
Abstrakt: Interconversions between epithelial and mesenchymal states, often referred to as epithelial mesenchymal transition (EMT) and its reverse MET, play important roles in embryonic development and are recapitulated in various adult pathologies including cancer progression. These conversions are regulated by complex transcriptional and post-transcriptional mechanisms including programs of alternative splicing which are orchestrated by specific splicing factors. This review will focus on the latest developments in our understanding of the splicing factors regulating epithelial mesenchymal plasticity associated with cancer progression and the induction of pluripotency, including potential roles for circular RNAs (circRNAs) which have been recently implicated in these processes.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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