Expert Opinion -Cognitive Decline in Heart Failure: More Attention is Needed.

Autor:	Čelutkienė J; Department of Cardiovascular Diseases, Vilnius University, Vilnius, Lithuania., Vaitkevičius A; Department of Neurology and Neurosurgery, Vilnius University, Vilnius, Lithuania., Jakštienė S; Department of Radiology, Lithuanian University of Health Sciences, Vilnius, Lithuania., Jatužis D; Department of Neurology and Neurosurgery, Vilnius University, Vilnius, Lithuania.
Jazyk:	angličtina
Zdroj:	Cardiac failure review [Card Fail Rev] 2016 Nov; Vol. 2 (2), pp. 106-109.
DOI:	10.15420/cfr.2016:19:2
Abstrakt:	Cognitive decline is a prevalent condition and independent prognostic marker of unfavourable outcomes in patients with heart failure. The highest prevalence, up to 80 %, is reported in patients hospitalised due to acute decompensation. Numerous factors contribute to cognitive dysfunction in heart failure patients, with hypertension, atrial fibrillation, stroke and impaired haemodynamics being the most relevant. Cerebral hypoperfusion, disruption of blood-brain barrier, oxidative damage and brain-derived cytokines are pathogenic links between heart failure and alteration of cognitive functioning. White matter hyperintensities, lacunar infarcts and generalised volume loss are common features revealed by neuroimaging. Typically affected cognitive domains are presented. Assessment of cognitive functioning, even by simple screening tests, should be part of routine clinical examination of heart failure patients. Competing Interests: Disclosure: The authors have no conflicts of interest to declare.
Databáze:	MEDLINE
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