The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Bacillus anthracis Infection in BALB/c Mice and Cynomolgus Macaques.
Autor: | Grossman TH; Tetraphase Pharmaceuticals, Inc., Watertown, Massachusetts, USA tgrossman@yahoo.com., Anderson MS; Battelle, Columbus, Ohio, USA., Drabek L; IIT Research Institute, Chicago, Illinois, USA., Gooldy M; CUBRC, Inc., Buffalo, New York, USA., Heine HS; United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA., Henning LN; Battelle, Columbus, Ohio, USA., Lin W; IIT Research Institute, Chicago, Illinois, USA., Newman JV; Tetraphase Pharmaceuticals, Inc., Watertown, Massachusetts, USA., Nevarez R; IIT Research Institute, Chicago, Illinois, USA., Siefkas-Patterson K; IIT Research Institute, Chicago, Illinois, USA., Radcliff AK; CUBRC, Inc., Buffalo, New York, USA., Sutcliffe JA; Tetraphase Pharmaceuticals, Inc., Watertown, Massachusetts, USA. |
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Jazyk: | angličtina |
Zdroj: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Sep 22; Vol. 61 (10). Date of Electronic Publication: 2017 Sep 22 (Print Publication: 2017). |
DOI: | 10.1128/AAC.01103-17 |
Abstrakt: | The fluorocycline TP-271 was evaluated in mouse and nonhuman primate (NHP) models of inhalational anthrax. BALB/c mice were exposed by nose-only aerosol to Bacillus anthracis Ames spores at a level of 18 to 88 lethal doses sufficient to kill 50% of exposed individuals (LD (Copyright © 2017 American Society for Microbiology.) |
Databáze: | MEDLINE |
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