| Autor: |
Bodansky HJ, Grant PJ, Dean BM, McNally J, Bottazzo GF, Hambling MH, Wales JK |
| Jazyk: |
angličtina |
| Zdroj: |
Lancet (London, England) [Lancet] 1986 Dec 13; Vol. 2 (8520), pp. 1351-3. |
| DOI: |
10.1016/s0140-6736(86)92003-9 |
| Abstrakt: |
The appearance of islet-cell antibodies (ICA) and insulin autoantibodies (IAA) was sought in a prospective study of subjects with acute infections (mumps, rubella, chickenpox, and measles) followed for 6 months. IAA appeared in many patients' serum samples after these acute infections, IgM-IAA being more prevalent than IgG-IAA; there was a particularly high incidence (81%) after chickenpox. ICA were detected in 2 subjects--in 1 after rubella and in the other after measles, but this patient had evidence of previous rubella and a strong autoimmune family history. ICA did not appear after mumps. It is postulated that viral infections may trigger the production of IgM-IAA by a common mechanism involving polyclonal immunocyte activation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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