A Continuous, Long-Term Plasmodium vivax In Vitro Blood-Stage Culture: What Are We Missing?

Autor: Thomson-Luque R; Center for Global Health & Infectious Diseases Research, Department of Global Health, College of Public Health, University of South Florida, Tampa, FL, USA., Shaw Saliba K; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kocken CHM; Biomedical Primate Research Centre, Rijswijk, The Netherlands., Pasini EM; Biomedical Primate Research Centre, Rijswijk, The Netherlands. Electronic address: pasini@bprc.nl.
Jazyk: angličtina
Zdroj: Trends in parasitology [Trends Parasitol] 2017 Dec; Vol. 33 (12), pp. 921-924. Date of Electronic Publication: 2017 Aug 02.
DOI: 10.1016/j.pt.2017.07.001
Abstrakt: The recent research efforts to establish a Plasmodium vivax continuous, long-term blood-stage culture have focused on the ideal host cell type. However, this is only part of the story, as the P. vivax intraerythrocytic life cycle is complex. A successful, long-term, robust culture system will depend on a multifaceted approach combining the ideal cell type and parasite isolates, and the culture conditions.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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