Multi-dose vitamin d supplementation in stable very preterm infants: Prospective randomized trial response to three different vitamin D supplementation doses.

Autor: Bozkurt O; Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. Electronic address: dr_kalyoncu@hotmail.com., Uras N; Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey., Sari FN; Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey., Atay FY; Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey., Sahin S; Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey., Alkan AD; Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey., Canpolat FE; Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey., Oguz SS; Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Early human development [Early Hum Dev] 2017 Sep; Vol. 112, pp. 54-59. Date of Electronic Publication: 2017 Aug 02.
DOI: 10.1016/j.earlhumdev.2017.07.016
Abstrakt: Background: Preterm newborns are born with lower vitamin D stores. Although vitamin D supplementation is recommended there is no consensus regarding the adequate dose of supplementation for preterm infants.
Aims: To assess the effect of three different doses of vitamin D supplementation (400, 800 and 1000IU/d) in preterm infants ≤32weeks gestation on the prevalence of vitamin D deficiency and 25(OH) D levels at 36weeks postmenstrual age (PMA).
Study Design: Prospective randomized trial.
Subjects: 121 preterm infants with gestational age of 24-32weeks were randomly allocated to receive 400, 800 or 1000IU/d vitamin D.
Outcome Measures: Serum concentration of 25(OH) D and the prevalence of vitamin D deficiency at 36weeks PMA. Vitamin D deficiency was defined as serum 25(OH) D concentrations <20ng/ml.
Results: Of the 121 infants 72% had deficient vitamin D levels before supplementation. The average 25(OH) vitamin D concentrations at 36weeks PMA were significantly higher in 800IU (40±21.4ng/ml) and 1000IU group (43±18.9ng/ml) when compared to 400IU group (29.4±13ng/ml). The prevalence of vitamin D deficiency (2.5 vs 22.5; RR: 0.09; CI:0.01-0.74) and insufficiency (30 vs 57.5; RR:0.32; CI:0.13-0.80) was significantly lower in 1000IU group when compared to 400IU group at 36weeks PMA.
Conclusion: 1000IU/d of vitamin D supplementation in preterm infants ≤32weeks gestation age effectively decreases the prevalence of vitamin D deficiency and leads to higher concentrations of 25(OH) vitamin D at 36weeks PMA TRIAL REGISTRATION: Clinical Trials.gov: NCT02941185.
(Copyright © 2017. Published by Elsevier B.V.)
Databáze: MEDLINE
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