Partitioning of hexachlorobenzene between human milk and blood lipid.

Autor: Palkovičová Murínová Ľ; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia., Wimmerová S; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia., Lancz K; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia., Patayová H; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia., Koštiaková V; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia., Richterová D; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia., Govarts E; Unit Environmental Risk and Health, VITO NV, Boeretang 200, 2400 Mol, Belgium., Jusko TA; Departments of Public Health Sciences and Environmental Medicine, University of Rochester, School of Medicine & Dentistry, 265 Crittenden Blvd, CU 420644, Rochester, NY 14642, United States., Trnovec T; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, Limbová 12, 833 03 Bratislava, Slovakia. Electronic address: tomas.trnovec@szu.sk.
Jazyk: angličtina
Zdroj: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2017 Oct; Vol. 229, pp. 994-999. Date of Electronic Publication: 2017 Aug 01.
DOI: 10.1016/j.envpol.2017.07.087
Abstrakt: In epidemiological studies on the toxic effects of prenatal exposure to hexachlorobenzene (HCB), researchers report HCB concentrations, either as wet-weight or per lipid weight basis, in matrices like breast milk, and maternal and cord blood. Conversion of exposures across matrices is needed for comparisons of concentrations and dose effect across cohorts. Using data from a birth cohort study in eastern Slovakia, we derived the maternal blood to cord blood HCB concentration ratio utilizing measured concentrations in 1027 paired maternal and cord blood samples, on a per-lipid basis. In addition to data from the Slovak study, the maternal milk to maternal serum ratio was summarized from 23 published studies on partitioning of HCB between human milk lipid and blood lipid. We identified two distinct groups of milk:blood ratios, those ≤0.45 and those ≥0.85. We assumed that using partition ratios ≤0.45 will underestimate HCB exposure estimates. Taking into account this precautionary measure, we suggest a conversion ratio of 1.21, which is the median of the 16 ratios identified in our literature review. We consider our estimate as conservative and providing appropriate safety in risk analysis.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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