The HLA DRB1*03:01 allele is associated with NMO regardless of the NMO-IgG status in Brazilian patients from Rio de Janeiro.

Autor: Alvarenga MP; Neurology Department, Hospital Federal da Lagoa, Rio de Janeiro, Brazil; Neurology Department, UNIRIO, Rio de Janeiro, Brazil., Fernandez O; Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Spain., Leyva L; Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Spain., Campanella L; Neurology Department, UNIRIO, Rio de Janeiro, Brazil., Vasconcelos CF; Neurology Department, UNIRIO, Rio de Janeiro, Brazil., Alvarenga M; Neurology Department, Hospital Federal da Lagoa, Rio de Janeiro, Brazil; Neurology Department, UNIRIO, Rio de Janeiro, Brazil., Papais Alvarenga RM; Neurology Department, Hospital Federal da Lagoa, Rio de Janeiro, Brazil; Neurology Department, UNIRIO, Rio de Janeiro, Brazil. Electronic address: ppgneuro@unirio.br.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2017 Sep 15; Vol. 310, pp. 1-7. Date of Electronic Publication: 2017 May 31.
DOI: 10.1016/j.jneuroim.2017.05.018
Abstrakt: The aim of this study was to analyze the HLA class II alleles in neuromyelitis optica (NMO) and MS patients from Rio de Janeiro to clarify whether the pattern of genetic predisposition in NMO is different from the one seen in MS or whether it is possible to determine specific alleles of susceptibility or resistance. The DR3 haplotype was over represented in NMO while the DR15 was over represented in MS. The HLA-DRB1*03:01 allele was associated with NMO regardless the NMO-IgG status but did not influence the long term disability. The comparison of the allele and haplotype frequencies significantly discriminated patients with NMO vs. MS.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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