Induction of virus resistance by exogenous application of double-stranded RNA.

Autor: Mitter N; Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia. Electronic address: n.mitter@uq.edu.au., Worrall EA; Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Robinson KE; Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Xu ZP; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Carroll BJ; School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
Jazyk: angličtina
Zdroj: Current opinion in virology [Curr Opin Virol] 2017 Oct; Vol. 26, pp. 49-55. Date of Electronic Publication: 2017 Aug 03.
DOI: 10.1016/j.coviro.2017.07.009
Abstrakt: Exogenous application of double-stranded RNA (dsRNA) for virus resistance in plants represents a very attractive alternative to virus resistant transgenic crops or pesticides targeting virus vectors. However, the instability of dsRNA sprayed onto plants is a major challenge as spraying naked dsRNA onto plants provides protection against homologous viruses for only 5 days. Innovative approaches, such as the use of nanoparticles as carriers of dsRNA for improved stability and sustained release, are emerging as key disruptive technologies. Knowledge is still limited about the mechanism of entry, transport and processing of exogenously applied dsRNA in plants. Cost of dsRNA and regulatory framework will be key influencers towards practical adoption of this technology.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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