Prevalence and Genetic Characteristics of Staphylococcus aureus and Staphylococcus argenteus Isolates Harboring Panton-Valentine Leukocidin, Enterotoxins, and TSST-1 Genes from Food Handlers in Myanmar.

Autor: Aung MS; Department of Hygiene, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan. meijisoeaung@sapmed.ac.jp., San T; National Health Laboratory, Department of Health, Yangon 11191, Myanmar. drthidarsan@gmail.com., Aye MM; University of Medical Technology, Mandalay 05072, Myanmar. prof.myamyaaye.umtm@gmail.com., Mya S; National Health Laboratory, Department of Health, Yangon 11191, Myanmar. dr.sanmya@gmail.com., Maw WW; University of Medicine 2, Yangon 11031, Myanmar. winwinmawizumo@gmail.com., Zan KN; National Health Laboratory, Department of Health, Yangon 11191, Myanmar. dr.khinnyeinzan@gmail.com., Htut WHW; New Yangon General Hospital, Yangon 11191, Myanmar. withmone.wh@gmail.com., Kawaguchiya M; Department of Hygiene, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan. kawaguchiya@sapmed.ac.jp., Urushibara N; Department of Hygiene, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan. noriko-u@sapmed.ac.jp., Kobayashi N; Department of Hygiene, School of Medicine, Sapporo Medical University, Sapporo 060-8556, Japan. nkobayas@sapmed.ac.jp.
Jazyk: angličtina
Zdroj: Toxins [Toxins (Basel)] 2017 Aug 04; Vol. 9 (8). Date of Electronic Publication: 2017 Aug 04.
DOI: 10.3390/toxins9080241
Abstrakt: Asymptomatic carriers of toxigenic Staphylococcus aureus are potential source of diseases, including food poisoning. Toxigenic potential and genetic traits of colonizing S. aureus were investigated for 563 healthy food handlers in Myanmar. Carriage of S. aureus was found in 110 individuals (19.5%), and a total of 144 S. aureus isolates were recovered from nasal cavities (110 isolates) and hands (34 isolates). Panton-Valentine leucocidin genes ( pvl ) were detected in 18 isolates (12.5%), among which 11 isolates were classified into coa -VIa, agr type III, and ST1930 (CC96) that had been also detected in pvl -positive clinical isolates in Myanmar. A pvl -positive, ST2250 nasal isolate was identified as S. argenteus , a novel coagulase-positive staphylococcus species. Toxic shock syndrome toxin-1 (TSST-1) gene was detected in five pvl -negative isolates. All of the 144 isolates harbored at least one of the 21 enterotoxin(-like) gene(s). The most prevalent enterotoxin(-like) gene was selw (98%), followed by selx (97%), sei (28%), sely (28%), sem (26%), sel (24%), and sea and sec (22% each). Considerable genetic diversity with five groups was detected for selw . The present study revealed the relatively high rate of pvl , as well as the wide distribution of enterotoxin(-like) genes among colonizing S. aureus in Myanmar.
Competing Interests: The authors declare no conflict of interest. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.
Databáze: MEDLINE
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