Computational Study of the Effect of Cortical Porosity on Ultrasound Wave Propagation in Healthy and Osteoporotic Long Bones.

Autor: T Potsika V; Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, GR 45110 Ioannina, Greece. vpotsika@cc.uoi.gr., N Grivas K; Department of Mechanical Engineering and Aeronautics, University of Patras, GR 26500 Patras, Greece. grivas@mech.upatras.gr., Gortsas T; Department of Mechanical Engineering and Aeronautics, University of Patras, GR 26500 Patras, Greece. gortsas@mech.upatras.gr., Iori G; Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. gianluca.iori@charite.de., C Protopappas V; Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, GR 45110 Ioannina, Greece. vprotop@cc.uoi.gr., Raum K; Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. kay.raum@charite.de., Polyzos D; Department of Mechanical Engineering and Aeronautics, University of Patras, GR 26500 Patras, Greece. polyzos@mech.upatras.gr., I Fotiadis D; Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, GR 45110 Ioannina, Greece. fotiadis@cc.uoi.gr.; Foundation for Research and Technology-Hellas, Institute of Molecular Biology and Biotechnology, Department of Biomedical Research, GR 45110 Ioannina, Greece. fotiadis@cc.uoi.gr.
Jazyk: angličtina
Zdroj: Materials (Basel, Switzerland) [Materials (Basel)] 2016 Mar 17; Vol. 9 (3). Date of Electronic Publication: 2016 Mar 17.
DOI: 10.3390/ma9030205
Abstrakt: Computational studies on the evaluation of bone status in cases of pathologies have gained significant interest in recent years. This work presents a parametric and systematic numerical study on ultrasound propagation in cortical bone models to investigate the effect of changes in cortical porosity and the occurrence of large basic multicellular units, simply called non-refilled resorption lacunae (RL), on the velocity of the first arriving signal (FAS). Two-dimensional geometries of cortical bone are established for various microstructural models mimicking normal and pathological tissue states. Emphasis is given on the detection of RL formation which may provoke the thinning of the cortical cortex and the increase of porosity at a later stage of the disease. The central excitation frequencies 0.5 and 1 MHz are examined. The proposed configuration consists of one point source and multiple successive receivers in order to calculate the FAS velocity in small propagation paths (local velocity) and derive a variation profile along the cortical surface. It was shown that: (a) the local FAS velocity can capture porosity changes including the occurrence of RL with different number, size and depth of formation; and (b) the excitation frequency 0.5 MHz is more sensitive for the assessment of cortical microstructure.
Databáze: MEDLINE
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