Genetics of Sick Sinus Syndrome.
| Autor: | Anderson JB; The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, ML 7042, Cincinnati, OH 45229, USA., Benson DW |
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| Jazyk: | angličtina |
| Zdroj: | Cardiac electrophysiology clinics [Card Electrophysiol Clin] 2010 Dec; Vol. 2 (4), pp. 499-507. |
| DOI: | 10.1016/j.ccep.2010.09.001 |
| Abstrakt: | The sinoatrial node exhibits complex cellular and molecular structure and its proper function requires an intricate arrangement of its architecture. A better understanding of the genetic and molecular makeup of the sinoatrial node has led to improved understanding of its function as primary cardiac pacemaker and the abnormalities that may lead to sick sinus syndrome, a common clinical problem. Recently, genetic studies have begun to identify the molecular underpinnings of sick sinus syndrome. Taken together, these findings promise improved diagnosis and alternative therapies for sick sinus syndrome. (Copyright © 2010 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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