Temporal Relation Between Myocardial Fibrosis and Heart Failure With Preserved Ejection Fraction: Association With Baseline Disease Severity and Subsequent Outcome.

Autor:	Schelbert EB; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; UPMC Cardiovascular Magnetic Resonance Center, Heart and Vascular Institute, Pittsburgh, Pennsylvania.; Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania., Fridman Y; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; UPMC Cardiovascular Magnetic Resonance Center, Heart and Vascular Institute, Pittsburgh, Pennsylvania., Wong TC; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; UPMC Cardiovascular Magnetic Resonance Center, Heart and Vascular Institute, Pittsburgh, Pennsylvania.; Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania., Abu Daya H; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; UPMC Cardiovascular Magnetic Resonance Center, Heart and Vascular Institute, Pittsburgh, Pennsylvania., Piehler KM; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; UPMC Cardiovascular Magnetic Resonance Center, Heart and Vascular Institute, Pittsburgh, Pennsylvania.; Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania., Kadakkal A; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; UPMC Cardiovascular Magnetic Resonance Center, Heart and Vascular Institute, Pittsburgh, Pennsylvania., Miller CA; Centre for Imaging Sciences and Biomedical Imaging Institute, University of Manchester, Manchester, England., Ugander M; Department of Clinical Physiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Maanja M; Department of Clinical Physiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Kellman P; National Heart, Lung, and Blood Institute, Bethesda, Maryland., Shah DJ; Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas., Abebe KZ; Center for Clinical Trials and Data Coordination, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Simon MA; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania., Quarta G; Department of Cardiology, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy., Senni M; Department of Cardiology, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy., Butler J; Cardiology Division, Stony Brook University, Stony Brook, New York., Diez J; Program of Cardiovascular Diseases, Center for Applied Medical Research, Department of Cardiology and Cardiac Surgery, University Clinic, University of Navarra, Pamplona, Spain.; CIBERCV, Carlos III Institute of Health, Madrid, Spain., Redfield MM; Department of Medicine, Mayo Clinic, Rochester, Minnesota., Gheorghiade M; Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Jazyk:	angličtina
Zdroj:	JAMA cardiology [JAMA Cardiol] 2017 Sep 01; Vol. 2 (9), pp. 995-1006.
DOI:	10.1001/jamacardio.2017.2511
Abstrakt:	Importance: Among myriad changes occurring during the evolution of heart failure with preserved ejection fraction (HFpEF), cardiomyocyte-extracellular matrix interactions from excess collagen may affect microvascular, mechanical, and electrical function. Objective: To investigate whether myocardial fibrosis (MF) is similarly prevalent both in those with HFpEF and those at risk for HFpEF, similarly associating with disease severity and outcomes. Design, Setting, and Participants: Observational cohort study from June 1, 2010, to September 17, 2015, with follow-up until December 14, 2015, at a cardiovascular magnetic resonance (CMR) center serving an integrated health system. Consecutive patients with preserved systolic function referred for CMR were eligible. Cardiovascular magnetic resonance was used to exclude patients with cardiac amyloidosis (n = 19). Exposures: Myocardial fibrosis quantified by extracellular volume (ECV) CMR measures. Main Outcome and Measures: Baseline BNP; subsequent hospitalization for heart failure or death. Results: Of 1174 patients identified (537 [46%] female; median [interquartile range {IQR}] age, 56 [44-66] years), 250 were "at risk" for HFpEF given elevated brain-type natriuretic peptide (BNP) level; 160 had HFpEF by documented clinical diagnosis, and 745 did not have HFpEF. Patients either at risk for HFpEF or with HFpEF demonstrated similarly higher prevalence/extent of MF and worse prognosis compared with patients with no HFpEF. Among those at risk for HFpEF or with HFpEF, the actual diagnosis of HFpEF was not associated with significant differences in MF (median ECV, 28.2%; IQR, 26.2%-30.7% vs 28.3%; IQR, 25.5%-31.4%; P = .60) or prognosis (log-rank 0.8; P = .38). Over a median of 1.9 years, 61 patients at risk for HFpEF or with HFpEF experienced adverse events (19 hospitalization for heart failure, 48 deaths, 6 with both). In those with HFpEF, ECV was associated with baseline log BNP (disease severity surrogate) in multivariable linear regression models, and was associated with outcomes in multivariable Cox regression models (eg, hazard ratio 1.75 per 5% increase in ECV, 95% CI, 1.25-2.45; P = .001 in stepwise model) whether grouped with patients at risk for HFpEF or not. Conclusions and Relevance: Among myriad changes occurring during the apparent evolution of HFpEF where elevated BNP is prevalent, MF was similarly prevalent in those with or at risk for HFpEF. Conceivably, MF might precede clinical HFpEF diagnosis. Regardless, MF was associated with disease severity (ie, BNP) and outcomes. Whether cells and secretomes mediating MF represent therapeutic targets in HFpEF warrants further evaluation.
Databáze:	MEDLINE
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