[The possibilities for diagnostics of prescription of death coming based on the changes in the lumbar intervertebral disks (the comparison of the morphological, immunohistochemical and topographical findings)].

Autor:	Byval'tsev VA; Irkutsk State Medical University, Ministry of Health of the Russia, Irkutsk, Russia 664003; Irkutsk Research Centre of Surgery and Orthopedics, Irkutsk, Russia 664003; Irkutsk Railway Clinical Hospital, Irkutsk, Russia 664005; Irkutsk Medical Academy of Post-Graduate Education, Irkutsk, Russia 664049., Stepanov IA; Irkutsk State Medical University, Ministry of Health of the Russia, Irkutsk, Russia 664003., Semenov AV; Regional Bureau of Forensic Medical Expertise, Irkutsk, Russia, 664022., Perfil'ev DV; Regional Bureau of Forensic Medical Expertise, Irkutsk, Russia, 664022., Belykh EG; Irkutsk State Medical University, Ministry of Health of the Russia, Irkutsk, Russia 664003., Bardonova LA; Irkutsk State Medical University, Ministry of Health of the Russia, Irkutsk, Russia 664003., Nikiforov SB; Irkutsk Research Centre of Surgery and Orthopedics, Irkutsk, Russia 664003., Sudakov NP; Irkutsk Research Centre of Surgery and Orthopedics, Irkutsk, Russia 664003., Bespyatykh IV; Irkutsk Railway Clinical Hospital, Irkutsk, Russia 664005., Antipina SL; Irkutsk Railway Clinical Hospital, Irkutsk, Russia 664005.
Jazyk:	ruština
Zdroj:	Sudebno-meditsinskaia ekspertiza [Sud Med Ekspert] 2017; Vol. 60 (4), pp. 4-8.
DOI:	10.17116/sudmed20176044-8
Abstrakt:	The objective of the present study was the comprehensive analysis of the postmortem changes in the lumbar intervertebral disks within different periods after death. A total of seven vertebromotor segments were distinguished in the lumbosacral region of the vertebral column based on the examination of 7 corpses. All these segments were divided into three groups in accordance with the prescription of death coming as follows: up to 12 hours (group 1), between 12 and 24 hours (group 2), and between 24 and 36 hours (group 3) after death. The models of the segments thus obtained were subjected to the study by means of diffusion weighted MRI. The removed intervertebral disks were used for morphological and immunohistochemical investigations. The comparison of the diffusion coefficients (DI) revealed the significant difference between the intervertebral disks assigned to groups 1 and 2 (p<0.01). The number of the cells in the pulpal core, the vertebral end plate, and the fibrous ring in all the above groups of the intervertebral disks was significantly reduced (p<0.01). The analysis of the correlation dependence between cell density and diffusion coefficients has demonstrated the well apparent relationship between these characteristics of the intervertebral disks comprising groups 1 and 2. It is concluded that diffusion weighted MRI in the combination with the calculation of diffusion coefficients for the intervertebral disks provides a tool for diagnostics of prescription of death coming as confirmed by the results of the morphometric studies and immunohistochemical analysis.
Databáze:	MEDLINE
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