Treatment of epilepsy in patients with myasthenia gravis: Is really harder than it looks?

Autor: Lorenzoni PJ; Division of Neurology, Department of Internal Medicine, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Ducci RD; Division of Neurology, Department of Internal Medicine, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Tensini TS; Division of Neurology, Department of Internal Medicine, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Dalledone G; Division of Neurology, Department of Internal Medicine, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Kay CSK; Division of Neurology, Department of Internal Medicine, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., de Paola L; Division of Neurology, Department of Internal Medicine, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Werneck LC; Division of Neurology, Department of Internal Medicine, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Scola RH; Division of Neurology, Department of Internal Medicine, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Silvado C; Division of Neurology, Department of Internal Medicine, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil. Electronic address: carlos.silvado@hc.ufpr.br.
Jazyk: angličtina
Zdroj: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2017 Oct; Vol. 44, pp. 353-356. Date of Electronic Publication: 2017 Jul 29.
DOI: 10.1016/j.jocn.2017.06.067
Abstrakt: The relationship between myasthenia gravis (MG) and epilepsy has been rarely reported. As consequence, there are no specific guidelines for the management of these conditions when they mutually occur. We reported on three patients in whom epilepsy and MG are coexisting, but in different clinical settings. Two patients were treated with antiepileptic drugs which improved their symptoms. One patient has controlled the seizures after a successful anterior temporal lobectomy with no appreciable consequences to her MG. We discuss the difficulties in the management of epilepsy in patients with MG. In addition, we report on the first epileptic surgery in a MG patient, indicating that this surgical procedure as a safe option for the treatment of intractable epilepsy in patients with MG.
(Copyright © 2017. Published by Elsevier Ltd.)
Databáze: MEDLINE
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