[Risk factors associated with the development of early neurological complications in purulent meningitis in a pediatric population].

Autor:	Espinoza-Oliva MM; Servicio de Infectología Pediátrica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., México., Rizo-Santos DB; Servicio de Pediatría, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., México., Díaz-Peña R; Servicio de Infectología Pediátrica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., México., Ortega-Cortés R; Servicio de Pediatría, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., México., Barrera de León JC; División de Educación en Salud, UMAE, Hospital de Pediatría del Centro Médico Nacional de Occidente (CMNO), IMSS, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., México.
Jazyk:	Spanish; Castilian
Zdroj:	Gaceta medica de Mexico [Gac Med Mex] 2017 May-Jun; Vol. 153 (3), pp. 313-320.
Abstrakt:	Objective: To determine the risk factors associated with the development of early neurological complications in purulent meningitis in a pediatric population. Methods: This was a case-control study including 78 children aged one month to 16 years with purulent meningitis divided into two groups: cases, with early neurological complications (defined as those presenting < 72 hours from initiation of clinical manifestation), and controls, without early neurological complications. Clinical, serum laboratory, and cerebrospinal fluid (CSF). Results: Seventy-eight patients were included: cases, n = 33, and controls, n = 45. Masculine gender, 19 (57%) vs. feminine gender, 28 (62%) (p = 0.679). Median age in months, 36 months (range, 1-180) vs. 12 months (range, 1-168) (p = 0.377). Factors associated with neurological complications: convulsive crises on admission, p = 0.038, OR, 2.65 (range, 1.04-6.74); meningeal signs, p = 0.032, OR, 2.73 (range, 1.07-6.96); alteration of the alert state, p = 0.003, OR, 13.0 (range, 1.64-105.3); orotracheal intubation, p = 0.000, OR, 14.47 (range, 4.76-44.01); neurological deterioration, p = 0.000, OR, 9.60 (range, 3.02-30.46); turbid CSF, p = 0.003, OR, 4.20 (range, 1.57-11.20); hypoglycorrhachia, < 30 mg/dl, p = 0.001, OR, 9.2 (range, 3.24-26.06); and positive CSF culture, p = 0.001, OR, 16.5 (range, 1.97-138.1). Conclusions: The factors associated with early neurological complications included convulsive crises on admission, meningeal signs, alteration of the alert state, need for orotracheal intubation, turbid CSF, hypoglycorrhachia, and positive CSF culture.
Databáze:	MEDLINE
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