In Vitro Mechanical Property Evaluation of Chitosan-Based Hydrogels Intended for Vascular Graft Development.

Autor: Aussel A; University Bordeaux, 33000, Bordeaux, France.; INSERM, Bioingénierie tissulaire, U1026, 33000, Bordeaux, France.; CHU de Bordeaux, 33000, Bordeaux, France., Montembault A; University Lyon, Université Lyon 1, Ingénierie des Matériaux Polymères (IMP), CNRS UMR 5223, 69622, Villeurbanne Cedex, France., Malaise S; University Lyon, Université Lyon 1, Ingénierie des Matériaux Polymères (IMP), CNRS UMR 5223, 69622, Villeurbanne Cedex, France., Foulc MP; Rescoll, 8 Allée Geoffroy Saint-Hilaire, 33600, Pessac, France., Faure W; Rescoll, 8 Allée Geoffroy Saint-Hilaire, 33600, Pessac, France., Cornet S; CHU de Bordeaux, CIC 1401, 33000, Bordeaux, France., Aid R; INSERM, U1148, Laboratoire de recherche vasculaire translationnelle, 75000, Paris, France.; University Paris Diderot, Sorbonne Paris Cité, 75000, Paris, France., Chaouat M; INSERM, U1148, Laboratoire de recherche vasculaire translationnelle, 75000, Paris, France., Delair T; University Lyon, Université Lyon 1, Ingénierie des Matériaux Polymères (IMP), CNRS UMR 5223, 69622, Villeurbanne Cedex, France., Letourneur D; INSERM, U1148, Laboratoire de recherche vasculaire translationnelle, 75000, Paris, France.; University Paris Diderot, Sorbonne Paris Cité, 75000, Paris, France., David L; University Lyon, Université Lyon 1, Ingénierie des Matériaux Polymères (IMP), CNRS UMR 5223, 69622, Villeurbanne Cedex, France., Bordenave L; University Bordeaux, 33000, Bordeaux, France. laurence.bordenave@chu-bordeaux.fr.; INSERM, Bioingénierie tissulaire, U1026, 33000, Bordeaux, France. laurence.bordenave@chu-bordeaux.fr.; CHU de Bordeaux, 33000, Bordeaux, France. laurence.bordenave@chu-bordeaux.fr.; CHU de Bordeaux, CIC 1401, 33000, Bordeaux, France. laurence.bordenave@chu-bordeaux.fr.
Jazyk: angličtina
Zdroj: Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2017 Dec; Vol. 10 (5-6), pp. 480-488. Date of Electronic Publication: 2017 Jul 31.
DOI: 10.1007/s12265-017-9763-z
Abstrakt: Vascular grafts made of synthetic polymers perform poorly in cardiac and peripheral bypass applications. In these applications, chitosan-based materials can be produced and shaped to provide a novel scaffold for vascular tissue engineering. The goal of this study was to evaluate in vitro the mechanical properties of a novel chitosan formulation to assess its potential for this scaffold. Two chitosan-based hydrogel tubes were produced by modulating chitosan concentration. Based on the standard ISO 7198:1998, the hydrogel tubes were characterized in vitro in terms of suture retention strength, tensile strength, compliance, and burst pressure. By increasing chitosan concentration, suture retention value increased to reach 1.1 N; average burst strength and elastic moduli also increased significantly. The compliance seemed to exhibit a low value for chitosan tubes of high concentration. By modulating chitosan concentration, we produced scaffolds with suitable mechanical properties to be implanted in vivo and withstand physiological blood pressures.
Databáze: MEDLINE
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