The Emerging Role of The Eosinophil and Its Measurement in Chronic Cough.

Autor: Sadeghi MH; Respiratory Medicine, Castle Hill Hospital, Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Cottingham, UK., Morice AH; Respiratory Medicine, Castle Hill Hospital, Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Cottingham, UK.
Jazyk: angličtina
Zdroj: The open respiratory medicine journal [Open Respir Med J] 2017 Jun 30; Vol. 11, pp. 17-30. Date of Electronic Publication: 2017 Jun 30 (Print Publication: 2017).
DOI: 10.2174/1874306401711010017
Abstrakt: Although the aetiology of chronic cough in guidelines is clearly stated as asthma and related syndromes, gastro-oesophageal reflux disease (GORD), and upper airways disease, the inflammatory mechanisms underlying these conditions differ. Recent studies on asthma have increasingly focused on its molecular phenotypes instead of clinical characteristics. Here, we proposed the hypothesis that divides cough into two groups; the eosinophilic and neutrophilic. This division will enhance our ability to recognise the type of airway inflammation which, as a consequence will lead us to more targeted and personalized treatment approaches.
Databáze: MEDLINE