Morphological Characteristics of Residual Skin Surface Components Collected from the Surface of Facial Skin in Women of Different Age.

Autor:	Chalyk NE; Lycotec Ltd., Cambridge, United Kingdom.; Saratov State Medical University named after V. I. Razumovsky, Institute of Cardiology of the Ministry of Health of the Russian Federation, Saratov, Russian Federation., Bandaletova TY; DiagNodus Ltd., Cambridge, United Kingdom., Kyle NH; Lycotec Ltd., Cambridge, United Kingdom., Petyaev IM; Lycotec Ltd., Cambridge, United Kingdom.
Jazyk:	angličtina
Zdroj:	Annals of dermatology [Ann Dermatol] 2017 Aug; Vol. 29 (4), pp. 454-461. Date of Electronic Publication: 2017 Jun 21.
DOI:	10.5021/ad.2017.29.4.454
Abstrakt:	Background: Problems of skin aging and its prevention currently attract increasing attention with the growth of human life expectancy. The morphology of the stratum corneum (SC) is well known, but investigation of age-related changes of its structure is difficult in the absence of non-invasive sampling methods. The residual skin surface components (RSSC) that overlay the SC can be easily collected non-invasively. Objective: The aim of this study was to examine morphology of RSSC samples collected from the surface of facial skin of healthy female volunteers of different age. Methods: RSSC samples were non-invasively collected from 53 adult female volunteers (22 aged in the range 18∼25 years and 31 aged in the range 50∼73 years). The samples were analysed microscopically. Results: Distinct age-related changes were determined for lipid droplet size, corneocyte desquamation level and lipid crystal count. There was a significant ( p =0.0006) decrease in lipid droplet size among older women. Similarly, significantly ( p =0.0401) lower lipid crystal numbers were present in the older group. Conversely, corneocyte desquamation was significantly higher ( p =0.0007) in older women. No age-related difference in microbial presence in the RSSC could be detected. Result patterns were generally similar to those previously found in male volunteers; however gender-related differences in the absolute values were revealed. Conclusion: Non-invasively collected RSSC samples allow identifying age-related changes on facial skin surface. The results of this study highlight gender-dependence of distinct elements of age-associated impairment of epidermal barrier and can be employed for developing new approaches to prevent changes associated with skin aging. Competing Interests: CONFLICTS OF INTEREST: The authors have nothing to disclose.
Databáze:	MEDLINE
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