Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma.

Autor: Fernández-Mateos J; Medical Oncology Service, University Hospital of Salamanca-IBSAL, Salamanca, 37007, Spain.; Biomedical Research Institute of Salamanca (IBSAL), SACYL-University of Salamanca-CSIC, Salamanca, 37007, Spain.; Molecular Medicine Unit- IBSAL, Department of Medicine, University of Salamanca, 37007, Salamanca, Spain.; Institute of Molecular and Cellular Biology of Cancer (IBMCC), University of Salamanca-CSIC, Salamanca, 37007, Spain., Seijas-Tamayo R; Medical Oncology Service, University Hospital of Salamanca-IBSAL, Salamanca, 37007, Spain.; Biomedical Research Institute of Salamanca (IBSAL), SACYL-University of Salamanca-CSIC, Salamanca, 37007, Spain., Klain JCA; Medical Oncology Service, University Hospital of Salamanca-IBSAL, Salamanca, 37007, Spain.; Biomedical Research Institute of Salamanca (IBSAL), SACYL-University of Salamanca-CSIC, Salamanca, 37007, Spain., Borgoñón MP; Medical Oncology Service, Hospital Universitario Politécnico La Fe, Valencia, 46026, Spain., Pérez-Ruiz E; Division of Medical Oncology, Oncology department, Agencia Sanitaria Hospital Costa del Sol de Marbella, 29603, Marbella, Spain., Mesía R; Medical Oncology Department, Universitat de Barcelona, IDIBELL, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, 08908, Spain., Del Barco E; Medical Oncology Service, University Hospital of Salamanca-IBSAL, Salamanca, 37007, Spain.; Biomedical Research Institute of Salamanca (IBSAL), SACYL-University of Salamanca-CSIC, Salamanca, 37007, Spain., Coloma CS; Medical Oncology Service, Hospital Universitario Politécnico La Fe, Valencia, 46026, Spain., Dominguez AR; Division of Medical Oncology, Oncology department, Agencia Sanitaria Hospital Costa del Sol de Marbella, 29603, Marbella, Spain., Daroqui JC; Medical Oncology Service, Hospital Universitario Politécnico La Fe, Valencia, 46026, Spain., Fernández Ruiz E; Otolaryngology Department, Agencia Sanitaria Hospital Costa del Sol de Marbella, Marbella, 29603, Spain., Cruz-Hernández JJ; Medical Oncology Service, University Hospital of Salamanca-IBSAL, Salamanca, 37007, Spain. ttcc@seom.org.; Biomedical Research Institute of Salamanca (IBSAL), SACYL-University of Salamanca-CSIC, Salamanca, 37007, Spain. ttcc@seom.org.; Molecular Medicine Unit- IBSAL, Department of Medicine, University of Salamanca, 37007, Salamanca, Spain. ttcc@seom.org.; Institute of Molecular and Cellular Biology of Cancer (IBMCC), University of Salamanca-CSIC, Salamanca, 37007, Spain. ttcc@seom.org., González-Sarmiento R; Biomedical Research Institute of Salamanca (IBSAL), SACYL-University of Salamanca-CSIC, Salamanca, 37007, Spain. gonzalez@usal.es.; Molecular Medicine Unit- IBSAL, Department of Medicine, University of Salamanca, 37007, Salamanca, Spain. gonzalez@usal.es.; Institute of Molecular and Cellular Biology of Cancer (IBMCC), University of Salamanca-CSIC, Salamanca, 37007, Spain. gonzalez@usal.es.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2017 Jul 31; Vol. 7 (1), pp. 6887. Date of Electronic Publication: 2017 Jul 31.
DOI: 10.1038/s41598-017-07270-0
Abstrakt: Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To investigate the importance of this pathway in HNSCC susceptibility, a risk factor matched case-control association study was performed with four candidate polymorphisms in autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma. ATG5 rs2245214 SNP was not associated with any location. Overall, our results indicate the importance of the autophagy pathway in the susceptibility of head and neck squamous cell carcinoma and demonstrate the heterogeneity between its locations encompassed under a single terminology.
Databáze: MEDLINE
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