Pulmonary mechanic and lung histology induced by Crotalus durissus cascavella snake venom.

Autor: Oliveira Neto J; Postgraduate Program in Veterinary Sciences, Faculty of Veterinary, State University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: joselitoneto@yahoo.com.br., Silveira JAM; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Serra DS; Postgraduate Program in Physics, State University of Ceará, Fortaleza, Ceará, Brazil., Viana DA; Postgraduate Program in Veterinary Sciences, Faculty of Veterinary, State University of Ceará, Fortaleza, Ceará, Brazil., Borges-Nojosa DM; Department of Biology, Federal University of Ceará, Fortaleza, Ceara, Brazil., Sampaio CMS; Department of Biology, State University of Ceará, Fortaleza, Ceará, Brazil., Monteiro HSA; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Cavalcante FSÁ; Postgraduate Program in Physics, State University of Ceará, Fortaleza, Ceará, Brazil., Evangelista JSAM; Postgraduate Program in Veterinary Sciences, Faculty of Veterinary, State University of Ceará, Fortaleza, Ceará, Brazil.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2017 Oct; Vol. 137, pp. 144-149. Date of Electronic Publication: 2017 Jul 28.
DOI: 10.1016/j.toxicon.2017.07.023
Abstrakt: This study have analyzed the pulmonary function in an experimental model of acute lung injury, induced by the Crotalus durissus cascavella venom (C. d. cascavella) (3.0 μg/kg - i.p), in pulmonary mechanic and histology at 1 h, 3 h, 6 h, 12 h and 24 h after inoculation. The C. d. cascavella venom led to an increase in Newtonian Resistance (R N ), Tissue Resistance (G) and Tissue Elastance (H) in all groups when compared to the control, particularly at 12 h and 24 h. The Histeresivity (η) increased 6 h, 12 h and 24 h after inoculation. There was a decrease in Static Compliance (C ST ) at 6 h, 12 h and 24 h and inspiratory capacity (IC) at 3 h, 6 h, 12 h and 24 h. C. d. cascavella venom showed significant morphological changes such as atelectasis, emphysema, hemorrhage, polymorphonuclear inflammatory infiltrate, edema and congestion. After a challenge with methacholine (MCh), R N demonstrated significant changes at 6, 12 and 24 h. This venom caused mechanical and histopathological changes in the lung tissue; however, its mechanisms of action need further studies in order to better elucidate the morphofunctional lesions.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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