Evaluation of endothelial dysfunction in patients with nonalcoholic fatty liver disease: Association of selenoprotein P with carotid intima-media thickness and endothelium-dependent vasodilation.

Autor: Cetindağlı I; GATA Haydarpasa Training Hospital, Department of Internal Medicine, 34668 Istanbul, Turkey., Kara M; GATA Haydarpasa Training Hospital, Department of Gastroenterology, 34668 Uskudar, Istanbul, Turkey., Tanoglu A; GATA Haydarpasa Training Hospital, Department of Gastroenterology, 34668 Uskudar, Istanbul, Turkey. Electronic address: alpaslantanoglu@yahoo.com., Ozalper V; GATA Haydarpasa Training Hospital, Department of Internal Medicine, 34668 Istanbul, Turkey., Aribal S; GATA Haydarpasa Training Hospital, Department of Radiology, 34668 Istanbul, Turkey., Hancerli Y; GATA Haydarpasa Training Hospital, Department of Internal Medicine, 34668 Istanbul, Turkey., Unal M; GATA Haydarpasa Training Hospital, Department of Radiology, 34668 Istanbul, Turkey., Ozarı O; GATA Haydarpasa Training Hospital, Department of Gastroenterology, 34668 Uskudar, Istanbul, Turkey., Hira S; GATA Haydarpasa Training Hospital, Department of Biochemistry, 34668 Istanbul, Turkey., Kaplan M; GATA Haydarpasa Training Hospital, Department of Internal Medicine, 34668 Istanbul, Turkey., Yazgan Y; GATA Haydarpasa Training Hospital, Department of Gastroenterology, 34668 Uskudar, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Clinics and research in hepatology and gastroenterology [Clin Res Hepatol Gastroenterol] 2017 Oct; Vol. 41 (5), pp. 516-524. Date of Electronic Publication: 2017 Jul 29.
DOI: 10.1016/j.clinre.2017.01.005
Abstrakt: Background: In patients with NAFLD, there is an increased risk of cardiovascular disease (CVD). Selenoprotein P (SelP), a hepatokine, is associated with insulin resistance (IR) and serum SelP was found to be elevated in patients with NAFLD.
Aim: This study aimed to determine the risk of CVD in NAFLD patients and the association of serum SelP levels with this NAFLD related CVD risk.
Methods: Ninety-three patients with NAFLD and 37 healthy controls were included in the study. Complete blood count, C-reactive protein (CRP), fasting glucose, serum lipid levels, and SelP levels were tested from fasting blood samples. Moreover, body mass index (BMI), HOMA-IR, carotid intima-media thickness (cIMT) and flow-mediated dilatation (FMD) were measured.
Results: In patients with NAFLD, the FMD ratio was significantly lower than in controls (P=0.027). cIMT measurements were similar in both groups (P=0.996). Serum SelP levels were significantly higher than controls (P<0.001). SelP levels were significantly correlated with BMI, fasting glucose, LDL-cholesterol and HOMA-IR (r=0.395, P<0.001; r=0.322, P=0.002; r=0.353, P<0.001; r=0.521, P<0.001, respectively). Also, SelP levels were significantly lower and correlated with FMD (r=-0.674, P<0.001). SelP, ESR and CRP were significantly higher (P<0.05) and FMD ratios were significantly lower (P<0.05) in patients with nonalcoholic steatohepatitis (NASH) when compared to patients with simple steatosis.
Conclusion: These results suggest that in young NAFLD patients without additional comorbidities, there is an increased risk of CVD. FMD may be a better predictor for assessment of CVD risk when compared with cIMT. We assume that there could also be an important role of SelP in the pathogenesis of NASH.
(Copyright © 2017 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: