| Autor: |
Djordjevic NZ; Department of Biomedical Sciences, State University of Novi Pazar, Vuka Karadzica bb, Novi Pazar, 36300, Serbia. natasadj@np.ac.rs., Paunović MG; Institute of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, Serbia., Peulić AS; Faculty of engineering, University of Kragujevac, Kragujevac, Serbia. |
| Jazyk: |
angličtina |
| Zdroj: |
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2017 Sep; Vol. 24 (27), pp. 21693-21699. Date of Electronic Publication: 2017 Jul 29. |
| DOI: |
10.1007/s11356-017-9710-1 |
| Abstrakt: |
In recent years, extremely low-frequency electromagnetic field (ELF-EMF) has received considerable attention for its potential biological effects. Numerous studies have shown the role of ELF-EMF in behaviour modulation. The aim of this study was to investigate the effect of short-term ELF-EMF (50 Hz) in the development of anxiety-like behaviour in rats through change hypothalamic oxidative stress and NO. Ten adult male rats (Wistar albino) were divided in two groups: control group-without exposure to ELF-EMF and experimental group-exposed to ELF-EMF during 7 days. After the exposure, time open field test and elevated plus maze were used to evaluate the anxiety-like behaviour of rats. Upon completion of the behavioural tests, concentrations of superoxide anion (O 2 · - ), nitrite (NO 2 - , as an indicator of NO) and peroxynitrite (ONOO - ) were determined in the hypothalamus of the animals. Obtained results show that ELF-EMF both induces anxiety-like behaviour and increases concentrations of O 2 · - and NO, whereas it did not effect on ONOO - concentration in hypothalamus of rats. In conclusion, the development of anxiety-like behaviour is mediated by oxidative stress and increased NO concentration in hypothalamus of rats exposed to ELF-EMF during 7 days. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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