Aryl-1H-imidazole[4,5f][1,10]phenanthroline Cu(II) complexes: Electrochemical and DNA interaction studies.

Autor: Rajebhosale BS; Department of Chemistry, Savitribai Phule Pune University, Pune 411007, India., Dongre SN; Department of Chemistry, Savitribai Phule Pune University, Pune 411007, India., Deshpande SS; Department of Chemistry, Savitribai Phule Pune University, Pune 411007, India., Kate AN; Department of Chemistry, Savitribai Phule Pune University, Pune 411007, India., Kumbhar AA; Department of Chemistry, Savitribai Phule Pune University, Pune 411007, India. Electronic address: aak@chem.unipune.ac.in.
Jazyk: angličtina
Zdroj: Journal of inorganic biochemistry [J Inorg Biochem] 2017 Oct; Vol. 175, pp. 129-137. Date of Electronic Publication: 2017 Jul 23.
DOI: 10.1016/j.jinorgbio.2017.07.008
Abstrakt: The reaction of aryl imidazo[4,5f] [1,10]phenanthrolines with Cu(NO 3 ) 2 lead to the formation of Cu(II) complexes of the type [Cu(L)(NO 3 ) 2 ] where L=PIP, 2-(phenyl) [4,5f] imidazo phenanthroline; HPIP=2-(2-hydroxyphenyl)imidazo [4,5f] phenanthroline and NIP=2-(naphthyl) [4,5f] imidazo phenanthroline. The interaction of these complexes with calf thymus DNA has been studied using viscosity measurements, UV-visible and fluorescence spectroscopy. Chemical nuclease activity of these complexes has also been investigated. All complexes cleave DNA via oxidative pathway involving singlet oxygen. Molecular docking studies revealed that these complexes bind to DNA through minor groove.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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