Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Autor: Wain LV; From the Department of Health Sciences (L.V.W., A.M.E., N. Shrine, C.B., T.B., M.D.T.), University of Leicester, United Kingdom., Vaez A; Department of Epidemiology (A.V., P.J.v.d.M., I.M.N., H. Snieder), University of Groningen, University Medical Center Groningen, The Netherlands.; Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Iran (A.V.)., Jansen R; Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, The Netherlands (R. Jansen)., Joehanes R; Hebrew SeniorLife, Harvard Medical School, Boston, MA (R. Joehanes).; National Heart, Lung and Blood Institute's Framingham Heart Study, MA (R. Joehanes, A.D.J., M. Larson)., van der Most PJ; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre (C.P.N., P.S.B., N.J.S.), University of Leicester, United Kingdom., Erzurumluoglu AM; From the Department of Health Sciences (L.V.W., A.M.E., N. Shrine, C.B., T.B., M.D.T.), University of Leicester, United Kingdom., O'Reilly PF; Institute of Psychiatry, Psychology and Neuroscience (P.F.O.), King's College London, United Kingdom., Cabrera CP; Clinical Pharmacology, William Harvey Research Institute (C.P.C., H.R.W., M.R.B., M. Brown, B.M., M.R., P.B.M., M.J.C.).; NIHR Barts Cardiovascular Biomedical Research Unit (C.P.C., H.R.W., M.R.B., M. Brown, P.B.M., M.J.C.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom., Warren HR; Clinical Pharmacology, William Harvey Research Institute (C.P.C., H.R.W., M.R.B., M. Brown, B.M., M.R., P.B.M., M.J.C.).; NIHR Barts Cardiovascular Biomedical Research Unit (C.P.C., H.R.W., M.R.B., M. Brown, P.B.M., M.J.C.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA (L.M.R., F.G., P.M.R., D.I.C.)., Verwoert GC; Department of Epidemiology (G.C.V., A. Hofman, A.G.U., O.H.F.), Erasmus MC, Rotterdam, The Netherlands., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit, Amsterdam, EMGO+ Institute, VU University Medical Center, The Netherlands (J.-J.H., E.J.d.G., G.W., D.I.B.)., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., M. Frånberg, A. Hamsten).; Centre for Molecular Medicine, Karolinska Universitetsjukhuset, Solna, Sweden (R.J.S., M. Frånberg, A. Hamsten)., Esko T; Estonian Genome Center (T.E., E.O., A. Metspalu), University of Tartu, Estonia.; Divisions of Endocrinology/Children's Hospital, Boston, MA (T.E.).; Broad Institute of Harvard and MIT, Cambridge, MA (T.E., C.M.L., C.N.-C.)., Arking DE; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (D.E.A., P.N., A. Chakravarti, G.B.E.)., Hwang SJ; The Population Science Branch, Division of Intramural Research, National Heart Lung and Blood Institute (S.-J.H., D.L.), National Institutes of Health, Bethesda, MD.; The Framingham Heart Study, Framingham, MA (S.-J.H., D.L.)., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics (X.G., J.Y.), LABioMed at Harbor-UCLA Medical Center, Torrance, CA., Kutalik Z; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland (Z.K., M. Bochud).; Swiss Institute of Bioinformatics, Lausanne, Switzerland (Z.K.)., Trompet S; Department of Cardiology (S. Trompet, J.W.J.), Leiden University Medical Center, The Netherlands., Shrine N; From the Department of Health Sciences (L.V.W., A.M.E., N. Shrine, C.B., T.B., M.D.T.), University of Leicester, United Kingdom., Teumer A; Institute for Community Medicine (A.T.), University Medicine Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Germany (A.T., M.D., U.V.)., Ried JS; Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany (J.S.R., A. Peters)., Bis JC; Cardiovascular Health Research Unit, Department of Medicine (J.C.B., B.M.P.), University of Washington, Seattle., Smith AV; Icelandic Heart Association, Kopavogur, Iceland (A.V.S., V. Gudnason).; Faculty of Medicine, University of Iceland, Reykjavik, Iceland (A.V.S., V. Gudnason)., Amin N; Genetic Epidemiology Unit, Department of Epidemiology (N.A., B.A.O., C.M.v.D.), Erasmus MC, Rotterdam, The Netherlands., Nolte IM; Department of Epidemiology (A.V., P.J.v.d.M., I.M.N., H. Snieder), University of Groningen, University Medical Center Groningen, The Netherlands., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.).; Department of Clinical Chemistry, Faculty of Medicine and Life Sciences, University of Tampere, Finland (L.-P.L., T.L.)., Mahajan A; Wellcome Trust Centre for Human Genetics (A. Mahajan, A.G., M. Farrall, T.F., C.M.L., H.W., A.P.M.), University of Oxford, United Kingdom., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, United Kingdom (N.J.W., J.L., C.L., R.J.F.L., R.A.S., J.H.Z.)., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology (E.H., R. Schmidt), Medical University Graz, Austria.; Institute of Medical Informatics, Statistics and Documentation (E.H.), Medical University Graz, Austria., Joshi PK; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics (P.K.J., H.C., I.R., S.W., J.F.W.), University of Edinburgh, Scotland, United Kingdom., Kristiansson K; Department of Health (K.K., A.S.H., T. Niiranen, P.J., A.J., S. Koskinen, P.K., V.S., M.P.), Helsinki, Finland., Traglia M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy (M.T., C.M.B., C.F.S., D.T.)., Havulinna AS; Department of Health (K.K., A.S.H., T. Niiranen, P.J., A.J., S. Koskinen, P.K., V.S., M.P.), Helsinki, Finland., Goel A; Division of Cardiovascular Medicine, Radcliffe Department of Medicine (A.G., M. Farrall, H.W.), University of Oxford, United Kingdom., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging (M.A.N.), National Institutes of Health, Bethesda, MD.; Data Tecnica International, Glen Echo, MD (M.A.N.)., Sõber S; Institute of Biomedicine and Translational Medicine (S.S., M. Laan), University of Tartu, Estonia., Vuckovic D; Medical Genetics, IRCCS-Burlo Garofolo Children Hospital, Trieste, Italy (D.V., G.G., P.G.).; Department of Medical, Surgical and Health Sciences, University of Trieste, Italy (D.V., I.G., M. Brumat, M. Cocca, A. Morgan, G.G., P.G.)., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, United Kingdom (N.J.W., J.L., C.L., R.J.F.L., R.A.S., J.H.Z.)., Del Greco M F; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy (F.D.G.M., P.P.P., A.S.P., A.A.H.)., Ayers KL; Department of Genetics and Genomic Sciences (K.L.A.), Icahn School of Medicine at Mount Sinai, New York., Marrugat J; Cardiovascular Epidemiology and Genetics, IMIM, and CIBERCV, Barcelona, Spain (J. Marrugat, R.E.)., Ruggiero D; Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Napoli, Italy (D.R., T. Nutile, R. Sorice, M. Ciullo)., Lopez LM; Centre for Cognitive Ageing and Cognitive Epidemiology (L.M.L., S.E.H., G.D., A.J.G., D.C.M.L., J.M.S., I.J.D.), University of Edinburgh, Scotland, United Kingdom.; Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin (L.M.L.).; UCD Conway Institute, Centre for Proteome Research (L.M.L.), University College Dublin, Belfield, Ireland., Niiranen T; Department of Health (K.K., A.S.H., T. Niiranen, P.J., A.J., S. Koskinen, P.K., V.S., M.P.), Helsinki, Finland., Enroth S; Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Sweden (S.E., Å. Johansson, U.G.)., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor (A.U.J., M. Boehnke)., Nelson CP; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre (C.P.N., P.S.B., N.J.S.), University of Leicester, United Kingdom.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester United Kingdom (C.P.N., P.S.B., N.J.S.)., Huffman JE; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (J.E.H., V.V., J. Marten, A.F.W., J.F.W.), University of Edinburgh, Western General Hospital, Scotland, United Kingdom., Zhang W; Department of Epidemiology and Biostatistics, School of Public Health (W.Z., E.E., J.C.C., H.G., B.L., I.T., A.-C.V.), Imperial College London, United Kingdom.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, United Kingdom (W.Z., J.C.C., J.S.K.)., Marten J; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (J.E.H., V.V., J. Marten, A.F.W., J.F.W.), University of Edinburgh, Western General Hospital, Scotland, United Kingdom., Gandin I; Department of Medical, Surgical and Health Sciences, University of Trieste, Italy (D.V., I.G., M. Brumat, M. Cocca, A. Morgan, G.G., P.G.)., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology (L.M.L., S.E.H., G.D., A.J.G., D.C.M.L., J.M.S., I.J.D.), University of Edinburgh, Scotland, United Kingdom.; Medical Genetics Section, Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine (S.E.H.), University of Edinburgh, Western General Hospital, Scotland, United Kingdom., Zemunik T; Department of Medical Biology, Faculty of Medicine, University of Split, Croatia (T.Z.)., Lu Y; The Charles Bronfman Institute for Personalized Medicine (Y.L., E.P.B., R.J.F.L.), Icahn School of Medicine at Mount Sinai, New York., Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health (W.Z., E.E., J.C.C., H.G., B.L., I.T., A.-C.V.), Imperial College London, United Kingdom.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Greece (E.E.)., Shah N; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Scotland, United Kingdom (N. Shah, A.S.F.D., C.N.A.P.).; Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan (N. Shah)., de Borst MH; Division of Nephrology, Department of Internal Medicine (M.H.d.B., M.A.S.), University of Groningen, University Medical Center Groningen, The Netherlands., Mangino M; Department of Twin Research and Genetic Epidemiology (M.M., C. Menni, T.D.S.), King's College London, United Kingdom.; National Institute for Health Research Biomedical Research Centre, London, United Kingdom (M.M.)., Prins BP; Department of Human Genetics, Wellcome Trust Sanger Institute, United Kingdom (B.P.P., E.Z.)., Campbell A; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine (A. Campbell), University of Edinburgh, Scotland, United Kingdom.; Generation Scotland, Centre for Genomic and Experimental Medicine (A. Campbell, S.P., C.H.), University of Edinburgh, Scotland, United Kingdom., Li-Gao R; Department of Clinical Epidemiology (R.L.-G., R.d.M., D.O.M.-K.), Leiden University Medical Center, The Netherlands., Chauhan G; INSERM U 1219, Bordeaux Population Health Center, France (G.C., C.T., S.D.).; Bordeaux University, France (G.C., C.T., S.D.)., Oldmeadow C; Hunter Medical Research Institute, New Lambton, NSW, Australia (C.O., E.G.H., R. Scott, J.A.)., Abecasis G; Center for Statistical Genetics, Department of Biostatistics, Ann Arbor, MI (G.A.)., Abedi M; Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Iran (M.A.)., Barbieri CM; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy (M.T., C.M.B., C.F.S., D.T.)., Barnes MR; Clinical Pharmacology, William Harvey Research Institute (C.P.C., H.R.W., M.R.B., M. Brown, B.M., M.R., P.B.M., M.J.C.).; NIHR Barts Cardiovascular Biomedical Research Unit (C.P.C., H.R.W., M.R.B., M. Brown, P.B.M., M.J.C.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom., Batini C; From the Department of Health Sciences (L.V.W., A.M.E., N. Shrine, C.B., T.B., M.D.T.), University of Leicester, United Kingdom., Beilby J; Busselton Population Medical Research Institute, Western Australia (J.B., J.H.).; PathWest Laboratory Medicine of Western Australia, Nedlands (J.B., J.H.).; School of Pathology and Laboratory Medicine (J.B., J.H.), The University of Western Australia, Nedlands., Blake T; From the Department of Health Sciences (L.V.W., A.M.E., N. Shrine, C.B., T.B., M.D.T.), University of Leicester, United Kingdom., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor (A.U.J., M. Boehnke)., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine (Y.L., E.P.B., R.J.F.L.), Icahn School of Medicine at Mount Sinai, New York., Braund PS; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre (C.P.N., P.S.B., N.J.S.), University of Leicester, United Kingdom.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester United Kingdom (C.P.N., P.S.B., N.J.S.)., Brown M; Clinical Pharmacology, William Harvey Research Institute (C.P.C., H.R.W., M.R.B., M. Brown, B.M., M.R., P.B.M., M.J.C.).; NIHR Barts Cardiovascular Biomedical Research Unit (C.P.C., H.R.W., M.R.B., M. Brown, P.B.M., M.J.C.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom., Brumat M; Department of Medical, Surgical and Health Sciences, University of Trieste, Italy (D.V., I.G., M. Brumat, M. Cocca, A. Morgan, G.G., P.G.)., Campbell H; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics (P.K.J., H.C., I.R., S.W., J.F.W.), University of Edinburgh, Scotland, United Kingdom., Chambers JC; Department of Epidemiology and Biostatistics, School of Public Health (W.Z., E.E., J.C.C., H.G., B.L., I.T., A.-C.V.), Imperial College London, United Kingdom.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, United Kingdom (W.Z., J.C.C., J.S.K.).; Imperial College Healthcare NHS Trust, London, United Kingdom (J.C.C., J.S.K.)., Cocca M; Department of Medical, Surgical and Health Sciences, University of Trieste, Italy (D.V., I.G., M. Brumat, M. Cocca, A. Morgan, G.G., P.G.)., Collins F; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute (F.C.), National Institutes of Health, Bethesda, MD., Connell J; University of Dundee, Ninewells Hospital & Medical School, United Kingdom (J.C.)., Cordell HJ; Institute of Genetic Medicine (H.J.C.), Newcastle University, Newcastle upon Tyne, United Kingdom., Damman JJ; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA (L.M.R., F.G., P.M.R., D.I.C.)., Davies G; Centre for Cognitive Ageing and Cognitive Epidemiology (L.M.L., S.E.H., G.D., A.J.G., D.C.M.L., J.M.S., I.J.D.), University of Edinburgh, Scotland, United Kingdom.; Department of Psychology (G.D., D.C.M.L., A. Pattie, I.J.D.), University of Edinburgh, Scotland, United Kingdom., de Geus EJ; Department of Biological Psychology, Vrije Universiteit, Amsterdam, EMGO+ Institute, VU University Medical Center, The Netherlands (J.-J.H., E.J.d.G., G.W., D.I.B.)., de Mutsert R; Department of Clinical Epidemiology (R.L.-G., R.d.M., D.O.M.-K.), Leiden University Medical Center, The Netherlands., Deelen J; Department of Molecular Epidemiology (J.D.), Leiden University Medical Center, The Netherlands., Demirkale Y; Center for Information Technology (Y.D., P.J.M., Q.T.N.), National Institutes of Health, Bethesda, MD., Doney ASF; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Scotland, United Kingdom (N. Shah, A.S.F.D., C.N.A.P.)., Dörr M; Department of Internal Medicine B (M.D.), University Medicine Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Germany (A.T., M.D., U.V.)., Farrall M; Wellcome Trust Centre for Human Genetics (A. Mahajan, A.G., M. Farrall, T.F., C.M.L., H.W., A.P.M.), University of Oxford, United Kingdom.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine (A.G., M. Farrall, H.W.), University of Oxford, United Kingdom., Ferreira T; Wellcome Trust Centre for Human Genetics (A. Mahajan, A.G., M. Farrall, T.F., C.M.L., H.W., A.P.M.), University of Oxford, United Kingdom., Frånberg M; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., M. Frånberg, A. Hamsten).; Centre for Molecular Medicine, Karolinska Universitetsjukhuset, Solna, Sweden (R.J.S., M. Frånberg, A. Hamsten).; Department of Numerical Analysis and Computer Science, Stockholm University, Sweden (M. Frånberg)., Gao H; Department of Epidemiology and Biostatistics, School of Public Health (W.Z., E.E., J.C.C., H.G., B.L., I.T., A.-C.V.), Imperial College London, United Kingdom., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden (V. Giedraitis)., Gieger C; Helmholtz Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH), Neuherberg, Germany (C.G.)., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA (L.M.R., F.G., P.M.R., D.I.C.)., Gow AJ; Centre for Cognitive Ageing and Cognitive Epidemiology (L.M.L., S.E.H., G.D., A.J.G., D.C.M.L., J.M.S., I.J.D.), University of Edinburgh, Scotland, United Kingdom.; Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh, United Kingdom (A.J.G.)., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., M. Frånberg, A. Hamsten).; Centre for Molecular Medicine, Karolinska Universitetsjukhuset, Solna, Sweden (R.J.S., M. Frånberg, A. Hamsten)., Harris TB; Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging (T.B.H., L.J.L.)., Hofman A; Department of Epidemiology (G.C.V., A. Hofman, A.G.U., O.H.F.), Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (A. Hofman)., Holliday EG; Hunter Medical Research Institute, New Lambton, NSW, Australia (C.O., E.G.H., R. Scott, J.A.)., Hui J; Busselton Population Medical Research Institute, Western Australia (J.B., J.H.).; PathWest Laboratory Medicine of Western Australia, Nedlands (J.B., J.H.).; School of Pathology and Laboratory Medicine (J.B., J.H.), The University of Western Australia, Nedlands.; School of Population and Global Health (J.H.), The University of Western Australia, Nedlands., Jarvelin MR; MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health (M.-R.J., P.E.), Imperial College London, United Kingdom.; Center For Life-Course Health Research (M.-R.J.), University of Oulu, Finland.; Biocenter Oulu (M.-R.J.), University of Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Finland (M.-R.J.)., Johansson Å; Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Sweden (S.E., Å. Johansson, U.G.)., Johnson AD; National Heart, Lung and Blood Institute's Framingham Heart Study, MA (R. Joehanes, A.D.J., M. Larson).; National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD (A.D.J.)., Jousilahti P; Department of Health (K.K., A.S.H., T. Niiranen, P.J., A.J., S. Koskinen, P.K., V.S., M.P.), Helsinki, Finland., Jula A; Department of Health (K.K., A.S.H., T. Niiranen, P.J., A.J., S. Koskinen, P.K., V.S., M.P.), Helsinki, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Finland (M.K.).; Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Finland (M.K.)., Kathiresan S; Cardiovascular Research Center (S. Kathiresan, C.N.-C.).; Center for Human Genetics (S. Kathiresan), Massachusetts General Hospital, Boston.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (S. Kathiresan, C.N.-C.)., Khaw KT; Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom (K.-T.K.)., Kolcic I; Department of Public Health, Faculty of Medicine, University of Split, Croatia (I.K., O.P.)., Koskinen S; Department of Health (K.K., A.S.H., T. Niiranen, P.J., A.J., S. Koskinen, P.K., V.S., M.P.), Helsinki, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, United Kingdom (N.J.W., J.L., C.L., R.J.F.L., R.A.S., J.H.Z.)., Larson M; National Heart, Lung and Blood Institute's Framingham Heart Study, MA (R. Joehanes, A.D.J., M. Larson)., Launer LJ; Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging (T.B.H., L.J.L.)., Lehne B; Department of Epidemiology and Biostatistics, School of Public Health (W.Z., E.E., J.C.C., H.G., B.L., I.T., A.-C.V.), Imperial College London, United Kingdom., Liewald DCM; Centre for Cognitive Ageing and Cognitive Epidemiology (L.M.L., S.E.H., G.D., A.J.G., D.C.M.L., J.M.S., I.J.D.), University of Edinburgh, Scotland, United Kingdom.; Department of Psychology (G.D., D.C.M.L., A. Pattie, I.J.D.), University of Edinburgh, Scotland, United Kingdom., Lin L; Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Switzerland (L. Lin, F.M., G.B.E.)., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology (L. Lind, J.S.), Uppsala University, Sweden., Mach F; Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Switzerland (L. Lin, F.M., G.B.E.)., Mamasoula C; Institute of Health and Society (C. Mamasoula), Newcastle University, Newcastle upon Tyne, United Kingdom., Menni C; Department of Twin Research and Genetic Epidemiology (M.M., C. Menni, T.D.S.), King's College London, United Kingdom., Mifsud B; Clinical Pharmacology, William Harvey Research Institute (C.P.C., H.R.W., M.R.B., M. Brown, B.M., M.R., P.B.M., M.J.C.)., Milaneschi Y; Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands (Y.M., B.W.J.H.P.)., Morgan A; Department of Medical, Surgical and Health Sciences, University of Trieste, Italy (D.V., I.G., M. Brumat, M. Cocca, A. Morgan, G.G., P.G.)., Morris AD; School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Scotland, United Kingdom (A.D.M.)., Morrison AC; Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (A.C.M.)., Munson PJ; Center for Information Technology (Y.D., P.J.M., Q.T.N.), National Institutes of Health, Bethesda, MD., Nandakumar P; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (D.E.A., P.N., A. Chakravarti, G.B.E.)., Nguyen QT; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute (F.C.), National Institutes of Health, Bethesda, MD., Nutile T; Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Napoli, Italy (D.R., T. Nutile, R. Sorice, M. Ciullo)., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation (IPCE) (A.J.O., H.R., C.A.H.), University of Groningen, University Medical Center Groningen, The Netherlands., Oostra BA; Genetic Epidemiology Unit, Department of Epidemiology (N.A., B.A.O., C.M.v.D.), Erasmus MC, Rotterdam, The Netherlands., Org E; Estonian Genome Center (T.E., E.O., A. Metspalu), University of Tartu, Estonia., Padmanabhan S; Generation Scotland, Centre for Genomic and Experimental Medicine (A. Campbell, S.P., C.H.), University of Edinburgh, Scotland, United Kingdom.; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (S.P.), University of Glasgow, United Kingdom., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland (A. Palotie, S.R., A.-P.S., M.P.)., Paré G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada (G.P., S. Thériault)., Pattie A; Department of Psychology (G.D., D.C.M.L., A. Pattie, I.J.D.), University of Edinburgh, Scotland, United Kingdom., Penninx BWJH; Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands (Y.M., B.W.J.H.P.)., Poulter N; School of Public Health (N.P.), Imperial College London, United Kingdom., Pramstaller PP; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy (F.D.G.M., P.P.P., A.S.P., A.A.H.).; Department of Neurology, General Central Hospital, Bolzano, Italy (P.P.P.).; Department of Neurology, University of Lübeck, Germany (P.P.P.)., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland (O.T.R.).; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland (O.T.R.)., Ren M; Clinical Pharmacology, William Harvey Research Institute (C.P.C., H.R.W., M.R.B., M. 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Jazyk: angličtina
Zdroj: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2017 Sep; Vol. 70 (3), pp. e4-e19. Date of Electronic Publication: 2017 Jul 24.
DOI: 10.1161/HYPERTENSIONAHA.117.09438
Abstrakt: Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7 , TNXB , LRP12 , LOC283335 , SEPT9 , and AKT2 , and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA . Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
Databáze: MEDLINE