Plasma Amino-Terminal Propeptide of C-Type Natriuretic Peptide Concentration in Normal-Weight and Obese Children.

Autor: Topçu S; Ankara University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, Ankara, Turkey., Özhan B; Pamukkale University Faculty of Medicine, Department of Pediatric Endocrinology, Denizli, Turkey., Alkan A; Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Biostatistics, Ankara, Turkey., Akyol M; Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Biostatistics, Ankara, Turkey., Şimşek Orhon F; Ankara University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, Ankara, Turkey., Başkan S; Ankara University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, Ankara, Turkey., Ulukol B; Ankara University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, Ankara, Turkey., Berberoğlu M; Ankara University Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey., Şıklar Z; Ankara University Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey., Şatıroğlu Tufan NL; Ankara University Faculty of Medicine, Department of Forensic Medicine, Forensic Genetics Laboratory, Ankara, Turkey.; Ankara University Faculty of Medicine, Department of Pediatric Genetics, Molecular Genetics Laboratory, Ankara, Turkey., Tufan AÇ; Ankara Yıldırım Beyazıt University Faculty of Medicine, Department of Histology and Embryology, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Journal of clinical research in pediatric endocrinology [J Clin Res Pediatr Endocrinol] 2017 Dec 15; Vol. 9 (4), pp. 308-314. Date of Electronic Publication: 2017 Jul 24.
DOI: 10.4274/jcrpe.4543
Abstrakt: Objective: In studies on the relationship between amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) concentration and height velocity in children, CNP has been implicated as an emerging new growth marker during childhood. It has been reported that besides its well-studied role in growth, plasma CNP levels are reduced in overweight and/or obese adolescents, suggesting CNP as a potential biomarker in childhood obesity. The primary goal of this study was to test this hypothesis in a Turkish population.
Methods: Consent was taken from 317 children [ages 0-18 (158 girls, 159 boys)] and their parents. All subjects were physically examined; anthropometric measurements were obtained. Body mass index was calculated. During routine blood work, 1 mL extra blood was taken. Plasma NT-proCNP concentration was measured by enzyme-linked immunosorbent assay.
Results: Results confirmed the previously described relationship between plasma NT-proCNP concentration and growth velocity. Plasma NT-proCNP concentration showed a negative correlation with age, weight, and height in children. Gender was not a factor that alters the age-dependent plasma NT-proCNP concentration until puberty.
Conclusion: Unlike previous reports, plasma NT-proCNP concentration of overweight/obese children was not significantly lower than that of children with normal weight in age groups analyzed in a Turkish population. Thus, it is too early to conclude that CNP is a potential biomarker in childhood obesity. Further studies are necessary to address this question.
Databáze: MEDLINE
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