Living donor liver transplantation for neonatal fulminant hepatitis due to herpes simplex virus infection.

Autor: Vincenzi R; Hepatology and Liver Transplantation, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil.; A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil., Fonseca EA; Hepatology and Liver Transplantation, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil.; A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil., Roda KMO; Hepatology and Liver Transplantation, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil.; A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil., Porta G; Hepatology and Liver Transplantation, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil.; A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil., Candido HL; Hepatology and Liver Transplantation, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil.; A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil., Benavides MR; Hepatology and Liver Transplantation, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil.; A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil., Leite KRM; Department of Pathology, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil., Afonso RC; Hepatology and Liver Transplantation, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil.; A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil., Turine-Neto P; Hepatology and Liver Transplantation, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil.; A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil., Ribeiro CMF; Department of Pathology, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil., Chapchap P; Hepatology and Liver Transplantation, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil., Seda-Neto J; Hepatology and Liver Transplantation, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil.; A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Pediatric transplantation [Pediatr Transplant] 2017 Nov; Vol. 21 (7). Date of Electronic Publication: 2017 Jul 23.
DOI: 10.1111/petr.13021
Abstrakt: Although rare, ALF caused by disseminated HSV infection is associated with high mortality in the neonatal population. This condition is often diagnosed relatively late due to the absence of specific signs. We present a case involving a neonate with ALF submitted to living donor liver transplantation without a prior diagnosis. The patient had no skin or mucosal lesions, and IgM serology was negative for HSV-1 and HSV-2. Immunohistochemical staining of the liver explant was positive for herpes virus infection, and the patient subsequently received antiviral drug treatment, with a good outcome. Due to organ shortages and the rarity of the aforementioned condition, LT has seldom been reported for the treatment of ALF caused by herpes virus infection; however, LT may be the only option for neonates with fulminant hepatitis. The use of living donors in an urgent scenario is well established in Eastern countries and safely applicable for pediatric patients with ALF.
(© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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