Promising bio-composites of polypyrrole and chitosan: Surface protective and in vitro biocompatibility performance on 316L SS implants.

Autor: Kumar AM; Centre of Research Excellence in Corrosion, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia. Electronic address: madhanchem@gmail.com., Suresh B; Department of Pharmacology and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea., Das S; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, South Korea., Obot IB; Centre of Research Excellence in Corrosion, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia., Adesina AY; Department of Mechanical Engineering, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia., Ramakrishna S; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, South Korea; College of Medicine, Hanyang University, Seoul, South Korea. Electronic address: suresh.ramakris@gmail.com.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2017 Oct 01; Vol. 173, pp. 121-130. Date of Electronic Publication: 2017 May 30.
DOI: 10.1016/j.carbpol.2017.05.083
Abstrakt: Advanced biomedical materials can potentially be developed from combinations of natural biodegradable polymers and synthetic polymers. We synthesized bioactive composites based on polypyrrole/chitosan through in-situ electrochemical polymerization in oxalic acid medium. Surface characterization results revealed the influence of chitosan inclusion on polypyrrole (PPy) surface morphology. Contact angle results confirmed the enhancement in surface hydrophilicity due to the addition of chitosan into the PPy matrix. Electrochemical corrosion studies revealed that the composite coatings showed enhanced protective performance compared to pure PPy. Further, we investigated the effect of the composite coatings on the growth of MG-63 human osteoblast cells to assess their biocompatibility. Monte Carlo simulations were engaged to assess the interactions between the metal surface and composite coatings. The composite containing equal parts PPy and chitosan was found to be biocompatible; together with the corrosion protection results, the findings indicated that this bioactive coating material has potential for use in 316L SS implants.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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