Multimodal exercise training in multiple sclerosis: A randomized controlled trial in persons with substantial mobility disability.
| Autor: | Sandroff BM; University of Alabama at Birmingham, Department of Physical Therapy, United States. Electronic address: sandroff@uab.edu., Bollaert RE; University of Illinois at Urbana-Champaign, Department of Kinesiology and Community Health, United States., Pilutti LA; University of Ottawa, Interdisciplinary School of Health Sciences, Canada., Peterson ML; Bradley University, Department of Physical Therapy and Health Science, United States., Baynard T; University of Illinois at Chicago, Integrative Physiology Laboratory, Department of Kinesiology & Nutrition, United States., Fernhall B; University of Illinois at Chicago, Integrative Physiology Laboratory, Department of Kinesiology & Nutrition, United States., McAuley E; University of Illinois at Urbana-Champaign, Department of Kinesiology and Community Health, United States., Motl RW; University of Alabama at Birmingham, Department of Physical Therapy, United States. Electronic address: robmotl@uab.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Contemporary clinical trials [Contemp Clin Trials] 2017 Oct; Vol. 61, pp. 39-47. Date of Electronic Publication: 2017 Jul 19. |
| DOI: | 10.1016/j.cct.2017.07.016 |
| Abstrakt: | Background: Mobility disability is a common, debilitating feature of multiple sclerosis (MS). Exercise training has been identified as an approach to improve MS-related mobility disability. However, exercise randomized controlled trials (RCTs) on mobility in MS have generally not selectively targeted those with the onset of irreversible mobility disability. Objectives: The current multi-site RCT compared the efficacy of 6-months of supervised, multimodal exercise training with an active control condition for improving mobility, gait, physical fitness, and cognitive outcomes in persons with substantial MS-related mobility disability. Methods: 83 participants with substantial MS-related mobility disability underwent initial mobility, gait, fitness, and cognitive processing speed assessments and were randomly assigned to 6-months of supervised multimodal (progressive aerobic, resistance, and balance) exercise training (intervention condition) or stretching-and-toning activities (control condition). Participants completed the same outcome assessments halfway through and immediately following the 6-month study period. Results: There were statistically significant improvements in six-minute walk performance (F(2158)=3.12, p=0.05, η Conclusions: This RCT provides novel, preliminary evidence that multimodal exercise training may improve endurance walking performance and cognitive processing speed, perhaps based on improvements in cardiorespiratory capacity, in persons with MS with substantial mobility disability. This is critical for informing the development of multi-site exercise rehabilitation programs in larger samples of persons with MS-related mobility disability. (Copyright © 2017 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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