Structure of general-population antibody titer distributions to influenza A virus.

Autor:	Nhat NTD; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine, Nuffield Department of Clinical, Medicine, University of Oxford, Oxford, United Kingdom., Todd S; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Liverpool School of Tropical Medicine, Liverpool, United Kingdom., de Bruin E; Department of Viroscience, Erasmus Medical Centre, Rotterdam, Netherlands.; National Institute for Public Health and the Environment, Bilthoven, Netherlands., Thao TTN; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Vy NHT; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Quan TM; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Vinh DN; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., van Beek J; National Institute for Public Health and the Environment, Bilthoven, Netherlands., Anh PH; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Lam HM; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Hung NT; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Thanh NTL; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Huy HLA; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Ha VTH; Khanh Hoa Provincial Hospital, Nha Trang, Vietnam., Baker S; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine, Nuffield Department of Clinical, Medicine, University of Oxford, Oxford, United Kingdom., Thwaites GE; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine, Nuffield Department of Clinical, Medicine, University of Oxford, Oxford, United Kingdom., Lien NTN; Hue Provincial Hospital, Thua Thien Hue province, Vietnam., Hong TTK; Dak Lak General Hospital, Buon Ma Thuot, Vietnam., Farrar J; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; The Wellcome Trust, London, UK., Simmons CP; Microbiology and Immunology Department, University of Melbourne, Melbourne, Australia., Chau NVV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Koopmans M; Department of Viroscience, Erasmus Medical Centre, Rotterdam, Netherlands.; National Institute for Public Health and the Environment, Bilthoven, Netherlands., Boni MF; Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam. mfb9@psu.edu.; Centre for Tropical Medicine, Nuffield Department of Clinical, Medicine, University of Oxford, Oxford, United Kingdom. mfb9@psu.edu.; Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA. mfb9@psu.edu.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2017 Jul 20; Vol. 7 (1), pp. 6060. Date of Electronic Publication: 2017 Jul 20.
DOI:	10.1038/s41598-017-06177-0
Abstrakt:	Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population's natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states - naiveté, recent infection, non-recent infection, childhood infection - depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein using a continuous titer measurement from a protein microarray assay. We describe the distributions of antibody titers to subtypes 2009 H1N1 and H3N2. Using a model selection approach to fit mixture distributions, we show that 2009 H1N1 antibody titers fall into four titer subgroups and that H3N2 titers fall into three subgroups. For H1N1, our interpretation is that the two highest-titer subgroups correspond to recent and historical infection, which is consistent with 2009 pandemic attack rates. Similar interpretations are available for H3N2, but right-censoring of titers makes these interpretations difficult to validate.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu