Exercise Therapy in Juvenile Idiopathic Arthritis: A Systematic Review and Meta-Analysis.

Autor:	Kuntze G; Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. Electronic address: gkuntze@ucalgary.ca., Nesbitt C; Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada., Whittaker JL; Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada., Nettel-Aguirre A; Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Toomey C; Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada., Esau S; Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada., Doyle-Baker PK; Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada., Shank J; Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada., Brooks J; Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Benseler S; Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Emery CA; Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
Jazyk:	angličtina
Zdroj:	Archives of physical medicine and rehabilitation [Arch Phys Med Rehabil] 2018 Jan; Vol. 99 (1), pp. 178-193.e1. Date of Electronic Publication: 2017 Jul 18.
DOI:	10.1016/j.apmr.2017.05.030
Abstrakt:	Objective: To conduct a systematic review to evaluate the efficacy of exercise interventions in improving outcomes across domains of functioning and disability in children and adolescents with juvenile idiopathic arthritis (JIA). Data Sources: Seven electronic databases were systematically searched up to November 16, 2016. Study Selection: Original data, analytic prospective design, physical therapy-led exercise intervention evaluation, children and adolescents with JIA, and assessment of functional, structural, activity, participation, or quality of life outcomes. Data Extraction: Two authors screened search results, and discrepancies were resolved by consensus. Of 5037 potentially relevant studies, 9 randomized controlled trials and 1 cohort study were included and scored. Data Synthesis: Study quality (Downs and Black quality assessment tool) and level of evidence (Oxford Centre of Evidence-Based Medicine model) were assessed and meta-analysis conducted where appropriate. Alternatively, a descriptive summary approach was chosen. All randomized controlled trials were moderate-quality intervention studies (level 2b evidence; median Downs and Black score, 20 out of 32; range, 15-27). Interventions included aquatic, strengthening, proprioceptive, aerobic, and Pilates exercises. Pediatric activity capacity (Child Health Assessment Questionnaire) improved with exercise (mean difference, .45; 95% confidence interval, .05-.76). Furthermore, descriptive summaries indicated improved activity capacity, body function and structure (pain and muscle strength), and quality of life outcomes. Conclusions: Exercise therapy appears to be well tolerated and beneficial across clinically relevant outcomes in patients with JIA. The paucity of high-quality evidence and study heterogeneity limited the ability to provide conclusive, generalizing evidence for the efficacy of exercise therapy and to provide specific recommendations for clinical practice at this time. Future research evaluating exercise program implementation using validated outcomes and detailed adherence and safety assessment is needed to optimize clinical decision pathways in patients with JIA. (Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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