| Autor: |
Law A, Wallis SC, Powell LM, Pease RJ, Brunt H, Priestley LM, Knott TJ, Scott J, Altman DG, Miller GJ, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Lancet (London, England) [Lancet] 1986 Jun 07; Vol. 1 (8493), pp. 1301-3. |
| DOI: |
10.1016/s0140-6736(86)91222-5 |
| Abstrakt: |
60 of 83 middle-aged white men had an XbaI restriction site polymorphism within the coding sequence of the apolipoprotein B gene. Subjects homozygous and heterozygous for the presence of an XbaI restriction site had mean serum triglyceride levels 36% higher (p = 0.02) than those in homozygotes without the restriction site; there was a less substantial difference (p = 0.03) in serum cholesterol. The findings supported a dominant pattern of inheritance. The presence of this restriction site may increase the risk of atherosclerotic disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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