Impact of thyroid function abnormalities on reproductive hormones during menstrual cycle in premenopausal HIV infected females at NAUTH, Nnewi, Nigeria.

Autor: Ukibe NR; Department of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria., Ukibe SN; Department of Prosthesis and Orthotics, School of Health Technology, Federal University of Technology Owerri, Imo State, Nigeria., Emelumadu OF; Depatment of Community Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra, State Nigeria., Onyenekwe CC; Department of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria., Ahaneku JE; Department of Chemical pathology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria., Igwegbe AO; Department of Obstetrics and Gynecology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria., Monago IN; Department of Medical Services, Federal Polytechnic, Oko, Anambra State, Nigeria., Ilika AL; Depatment of Community Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra, State Nigeria.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2017 Jul 19; Vol. 12 (7), pp. e0176361. Date of Electronic Publication: 2017 Jul 19 (Print Publication: 2017).
DOI: 10.1371/journal.pone.0176361
Abstrakt: Background: This was a prospective study designed to evaluate the impact of thyroid function abnormalities on reproductive hormones during menstrual cycle in HIV infected females at Nnamdi Azikiwe University Teaching Hospital Nnewi, South-East Nigeria.
Methods: The study randomly recruited 35 Symptomatic HIV infected females and 35 Symptomatic HIV infected females on antiretroviral therapy (HAART) for not less than six weeks from an HIV clinic and 40 apparently heathy control females among the hospital staff of NAUTH Nnewi. They were all premenopausal females with regular menstrual cycle and aged between 15-45 years. Blood samples were collected at follicular and luteal phases of their menstrual cycle for assay of Thyroid indices (FT3, FT4 and TSH) and Reproductive indices (FSH, LH, Estrogen, Progesterone, Prolactin and Testosterone) using ELISA method.
Results: The result showed significantly higher FSH and LH but significantly lower progesterone (prog) and estrogen (E2) in the test females compared to control females at both phases of menstrual cycle (P<0.05). There was significantly lower FT3 but significantly higher TSH value in Symptomatic HIV females (P<0.05). FSH, LH and TSH values were significantly lowered while prog and FT3 were significantly higher in Symptomatic HIV on ART compared to Symptomatic HIV females (P<0.05). FT3, FT4, Prog and E2 were inversely correlated while FSH and LH were positively correlated with duration of HIV infection in HIV females (P<0.05 respectively). There was a direct correlation between CD4+ count and FT3 while inverse correlation was found between CD4+ count and TSH levels (P<0.05).
Discussion: The present study demonstrated hypothyroidism with a significant degree of primary hypogonadism in Symptomatic HIV infected females at both follicular and luteal phases of menstrual cycle which tends to normalize on treatments.
Databáze: MEDLINE
Externí odkaz: