| Autor: |
Olson D; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.; Center for Global Health, Colorado School of Public Health, Aurora, Colorado.; Children's Hospital Colorado, Aurora, Colorado.; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado., Lamb MM; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado.; Center for Global Health, Colorado School of Public Health, Aurora, Colorado., Lopez MR; Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City, Guatemala., Paniagua-Avila MA; Center for Public Health Initiatives, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, FUNSALUD, Quetzaltenango, Guatemala., Zacarias A; Center for Human Development, Fundacion para la Salud Integral de los Guatemaltecos, FUNSALUD, Quetzaltenango, Guatemala., Samayoa-Reyes G; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado.; Center for Global Health, Colorado School of Public Health, Aurora, Colorado., Cordon-Rosales C; Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City, Guatemala., Asturias EJ; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.; Children's Hospital Colorado, Aurora, Colorado.; Center for Global Health, Colorado School of Public Health, Aurora, Colorado.; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado. |
| Abstrakt: |
We examined burden and factors associated with norovirus (NoV) acute gastroenteritis (AGE) among children in rural Guatemala. Children age 6 weeks to 17 years were enrolled into three AGE surveillance groups, using two-stage cluster sampling: a prospective participatory syndromic surveillance (PSS) cohort and two cross-sectional rapid active sampling (RAS) surveys, conducted from April 2015 to February 2016. Epidemiologic and NoV testing data were used to identify factors associated with NoV infection, AGE, and NoV+ AGE. The three cross-sectional surveys (PSS enrollment visit, RAS Survey 1, and RAS Survey 2) enrolled 1,239 children, who reported 134 (11%) AGE cases, with 20% of AGE and 11% of non-AGE samples positive for NoV. Adjusted analyses identified several modifiable factors associated with AGE and NoV infection. The cross-sectional RAS surveys were practical and cost-effective in identifying population-level risk factors for AGE and NoV, supporting their use as a tool to direct limited public health resources toward high-risk populations. |
