Regular physical exercise improves cardiac autonomic and muscle vasodilatory responses to isometric exercise in healthy elderly.

Autor:	Sarmento AO; Laboratory of Physical Training Studies Applied to Health, Department of Physical Education, Federal University of Paraiba, João Pessoa, Brazil.; Unit of Cardiovascular Rehabilitation and Exercise Physiology - Heart Institute (InCor/HC-FMUSP), University of São Paulo, São Paulo, Brazil.; Graduate Program in Physiotherapy, Federal University of Pernambuco, Recife, Brazil., Santos ADC; Laboratory of Physical Training Studies Applied to Health, Department of Physical Education, Federal University of Paraiba, João Pessoa, Brazil.; Associate Graduate Program in Physical Education UPE/UFPB, João Pessoa, Brazil., Trombetta IC; Unit of Cardiovascular Rehabilitation and Exercise Physiology - Heart Institute (InCor/HC-FMUSP), University of São Paulo, São Paulo, Brazil.; Graduate Program in Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil., Dantas MM; Laboratory of Physical Training Studies Applied to Health, Department of Physical Education, Federal University of Paraiba, João Pessoa, Brazil., Oliveira Marques AC; Laboratory of Physical Training Studies Applied to Health, Department of Physical Education, Federal University of Paraiba, João Pessoa, Brazil.; Associate Graduate Program in Physical Education UPE/UFPB, João Pessoa, Brazil., do Nascimento LS; Laboratory of Physical Training Studies Applied to Health, Department of Physical Education, Federal University of Paraiba, João Pessoa, Brazil.; Associate Graduate Program in Physical Education UPE/UFPB, João Pessoa, Brazil., Barbosa BT; Laboratory of Physical Training Studies Applied to Health, Department of Physical Education, Federal University of Paraiba, João Pessoa, Brazil.; Unit of Cardiovascular Rehabilitation and Exercise Physiology - Heart Institute (InCor/HC-FMUSP), University of São Paulo, São Paulo, Brazil., Dos Santos MR; Unit of Cardiovascular Rehabilitation and Exercise Physiology - Heart Institute (InCor/HC-FMUSP), University of São Paulo, São Paulo, Brazil., Andrade MDA; Graduate Program in Physiotherapy, Federal University of Pernambuco, Recife, Brazil., Jaguaribe-Lima AM; Graduate Program in Physiotherapy, Federal University of Pernambuco, Recife, Brazil.; Department of Morphology and Animal Physiology, Federal Rural University of Pernambuco, Recife, Brazil., Brasileiro-Santos MDS; Laboratory of Physical Training Studies Applied to Health, Department of Physical Education, Federal University of Paraiba, João Pessoa, Brazil.; Graduate Program in Physiotherapy, Federal University of Pernambuco, Recife, Brazil.; Associate Graduate Program in Physical Education UPE/UFPB, João Pessoa, Brazil.
Jazyk:	angličtina
Zdroj:	Clinical interventions in aging [Clin Interv Aging] 2017 Jun 28; Vol. 12, pp. 1021-1028. Date of Electronic Publication: 2017 Jun 28 (Print Publication: 2017).
DOI:	10.2147/CIA.S120876
Abstrakt:	The objective of this study was to evaluate cardiac autonomic control and muscle vasodilation response during isometric exercise in sedentary and physically active older adults. Twenty healthy participants, 10 sedentary and 10 physically active older adults, were evaluated and paired by gender, age, and body mass index. Sympathetic and parasympathetic cardiac activity (spectral and symbolic heart rate analysis) and muscle blood flow (venous occlusion plethysmography) were measured for 10 minutes at rest (baseline) and during 3 minutes of isometric handgrip exercise at 30% of the maximum voluntary contraction (sympathetic excitatory maneuver). Variables were analyzed at baseline and during 3 minutes of isometric exercise. Cardiac autonomic parameters were analyzed by Wilcoxon and Mann-Whitney tests. Muscle vasodilatory response was analyzed by repeated-measures analysis of variance followed by Tukey's post hoc test. Sedentary older adults had higher cardiac sympathetic activity compared to physically active older adult subjects at baseline (63.13±3.31 vs 50.45±3.55 nu, P =0.02). The variance (heart rate variability index) was increased in active older adults (1,438.64±448.90 vs 1,402.92±385.14 ms, P =0.02), and cardiac sympathetic activity (symbolic analysis) was increased in sedentary older adults (5,660.91±1,626.72 vs 4,381.35±1,852.87, P =0.03) during isometric handgrip exercise. Sedentary older adults showed higher cardiac sympathetic activity (spectral analysis) (71.29±4.40 vs 58.30±3.50 nu, P =0.03) and lower parasympathetic modulation (28.79±4.37 vs 41.77±3.47 nu, P =0.03) compared to physically active older adult subjects during isometric handgrip exercise. Regarding muscle vasodilation response, there was an increase in the skeletal muscle blood flow in the second (4.1±0.5 vs 3.7±0.4 mL/min per 100 mL, P =0.01) and third minute (4.4±0.4 vs 3.9±0.3 mL/min per 100 mL, P =0.03) of handgrip exercise in active older adults. The results indicate that regular physical activity improves neurovascular control of muscle blood flow and cardiac autonomic response during isometric handgrip exercise in healthy older adult subjects. Competing Interests: Disclosure The authors report no conflicts of interest in this work.
Databáze:	MEDLINE
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