Remodeling of extracellular matrix of the lamina propria in the uninvolved human rectal mucosa 10 and 20 cm away from the malignant tumor.

Autor: Despotović SZ; 1 Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Milićević NM; 1 Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Milošević DP; 2 Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; 3 Department of Geriatrics, Zvezdara University Clinical Center, Belgrade, Serbia., Despotović N; 2 Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; 3 Department of Geriatrics, Zvezdara University Clinical Center, Belgrade, Serbia., Erceg P; 2 Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; 3 Department of Geriatrics, Zvezdara University Clinical Center, Belgrade, Serbia., Svorcan P; 2 Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; 4 Center for Gastroenterology and Hepatology, Zvezdara University Clinical Center, Belgrade, Serbia., Schumacher U; 5 Institute of Anatomy and Experimental Morphology, University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ullrich S; 5 Institute of Anatomy and Experimental Morphology, University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mihajlović G; 3 Department of Geriatrics, Zvezdara University Clinical Center, Belgrade, Serbia., Kalem D; 4 Center for Gastroenterology and Hepatology, Zvezdara University Clinical Center, Belgrade, Serbia., Marković S; 4 Center for Gastroenterology and Hepatology, Zvezdara University Clinical Center, Belgrade, Serbia., Lalić IM; 1 Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Krmpot AJ; 6 Institute of Physics, University of Belgrade, Belgrade, Serbia., Rabasović MD; 6 Institute of Physics, University of Belgrade, Belgrade, Serbia., Pantelić DV; 6 Institute of Physics, University of Belgrade, Belgrade, Serbia., Jovanić SZ; 6 Institute of Physics, University of Belgrade, Belgrade, Serbia., Rösch T; 7 Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Milićević Ž; 1 Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Jazyk: angličtina
Zdroj: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2017 Jul; Vol. 39 (7), pp. 1010428317711654.
DOI: 10.1177/1010428317711654
Abstrakt: In recent years, it has been demonstrated that malignancy arises and advances through the molecular interplay between tumor cells and non-malignant elements of the tumor stroma, that is, fibroblasts and extracellular matrix. However, in contrast to the mounting evidence about the role of tumor stroma in the genesis and progression of the malignant disease, there are very few data regarding the uninvolved stromal tissue in the remote surrounding of the tumor. Using the objective morphometric approach in patients with adenocarcinoma, we demonstrate the remodeling of extracellular matrix of the lamina propria in the uninvolved rectal mucosa 10 and 20 cm away from the neoplasm. We show that the representation of basic extracellular matrix constituents (reticular and collagen fibers and ground substance) is decreased. Also, the diameter of empty spaces that appear within the extracellular matrix of the lamina propria is increased. These spaces do not represent the blood or lymphatic vessel elements. Very likely, they reflect the development of tissue edema in the remote, uninvolved lamina propria of the mucosa in patients with the malignant tumor of the rectum. We hypothesize that the remodeling of extracellular matrix in lamina propria of the rectal mucosa may increase its stiffness, modulating the mechano-signal transduction, and thus promote the progression of the malignant disease.
Databáze: MEDLINE