Long-Term Cortisol Concentration in Scalp Hair of Asthmatic Children Using Inhaled Corticosteroids: A Case-Control Study.

Autor:	Smit MP; Department of Paediatrics, Groene Hart Hospital, Gouda, the Netherlands., van Leer EHG; Department of Paediatrics, Groene Hart Hospital, Gouda, the Netherlands., Noppe G; Department of Paediatrics and Internal Medicine, Sophia Children's Hospital-Erasmus MC, Rotterdam, the Netherlands., de Rijke YB; Department of Clinical Chemistry, Erasmus MC, Rotterdam, the Netherlands., Kramer van Driel D; Department of Paediatrics, Groene Hart Hospital, Gouda, the Netherlands., van den Akker ELT; Department of Paediatrics, Sophia Children's Hospital-Erasmus MC, Rotterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	Hormone research in paediatrics [Horm Res Paediatr] 2017; Vol. 88 (3-4), pp. 231-236. Date of Electronic Publication: 2017 Jul 14.
DOI:	10.1159/000478526
Abstrakt:	Introduction: Inhaled corticosteroids (ICS) can interfere with the hypothalamic-pituitary-adrenal (HPA) axis and may lead to adrenal insufficiency, resulting in a decrease of cortisol production. Cortisol levels measured in scalp hair provide a marker for long-term cortisol exposure. Data regarding hair cortisol concentration (HCC) in asthmatic children with ICS therapy are scarce. The aim of this study is to compare HCC in asthmatic children under ICS treatment with a healthy control group. Methods: We set up a case-control study measuring the cortisol concentration in scalp hair in asthmatic children (N = 80) treated with ICS and healthy controls (N = 252) aged 4-18 years. Anthropometric characteristics and hair samples from the posterior vertex were obtained. At least 5 mg of the most proximal 3 cm of hair was used for each hair sample. HCC was analyzed by liquid chromatography-tandem mass spectrometry. Results: HCC did not significantly differ between asthmatic children using ICS and healthy controls (p = 0.950) after adjustment for age, gender, height, body mass index, and socioeconomic status. No correlation was found between budesonide dosage and HCC levels (r = -0.031, p = 0.78). Conclusion: There was no evidence of suppression of basal cortisol production, as measured in scalp hair, in asthmatic children using ICS, compared to healthy controls. No conclusions can be drawn on the HPA-axis stress response in these children. (© 2017 S. Karger AG, Basel.)
Databáze:	MEDLINE
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