Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota.

Autor:	Diling C; State Key Laboratory of Applied Microbiology South China, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou, China., Chaoqun Z; State Key Laboratory of Applied Microbiology South China, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou, China.; College of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China., Jian Y; State Key Laboratory of Applied Microbiology South China, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou, China., Jian L; State Key Laboratory of Applied Microbiology South China, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou, China.; College of Chinese Materia Medica, Guangxi University of Traditional Chinese Medicine, Nanning, China., Jiyan S; State Key Laboratory of Applied Microbiology South China, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou, China., Yizhen X; State Key Laboratory of Applied Microbiology South China, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Yuewei Edible Fungi Technology Co., Ltd., Guangzhou, China., Guoxiao L; State Key Laboratory of Applied Microbiology South China, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.; Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou, China.; College of Chinese Materia Medica, Guangxi University of Traditional Chinese Medicine, Nanning, China.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2017 Jun 12; Vol. 8, pp. 666. Date of Electronic Publication: 2017 Jun 12 (Print Publication: 2017).
DOI:	10.3389/fimmu.2017.00666
Abstrakt:	A single-band protein (HEP3) was isolated from Hericium erinaceus using a chemical separation combined with pharmacodynamic evaluation methods. This protein exhibited immunomodulatory activity in lipopolysaccharide-activated RAW 264.7 macrophages by decreasing the overproduction of tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, and downregulating the expression of inducible nitric oxide synthase and nuclear factor-κB p65. Further researches revealed that HEP3 could improve the immune system via regulating the composition and metabolism of gut microbiota to activate the proliferation and differentiation of T cells, stimulate the intestinal antigen-presenting cells in high-dose cyclophosphamide-induced immunotoxicity in mice, and play a prebiotic role in the case of excessive antibiotics in inflammatory bowel disease model mice. Aided experiments also showed that HEP3 could be used as an antitumor immune inhibitor in tumor-burdened mice. The results of the present study suggested that fungal protein from H. erinaceus could be used as a drug or functional food ingredient for immunotherapy because of its immunomodulatory activities.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu