Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.

Autor:	Favuzzi E; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK; Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain., Marques-Smith A; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK., Deogracias R; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK; Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain., Winterflood CM; Randall Division of Cell and Molecular Biophysics, King's College London, London, SE1 1UL, UK., Sánchez-Aguilera A; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK., Mantoan L; Clinical Neurosciences Department, King's College, NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK., Maeso P; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK; Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain., Fernandes C; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK., Ewers H; Randall Division of Cell and Molecular Biophysics, King's College London, London, SE1 1UL, UK; Institute for Chemistry and Biochemistry, Free University Berlin, 14195 Berlin, Germany., Rico B; Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE1 1UL, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK; Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain. Electronic address: beatriz.rico@kcl.ac.uk.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2017 Aug 02; Vol. 95 (3), pp. 639-655.e10. Date of Electronic Publication: 2017 Jul 14.
DOI:	10.1016/j.neuron.2017.06.028
Abstrakt:	Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function. (Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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