Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior.

Autor:	McCall JG; Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, United States.; Washington University Pain Center, Washington University School of Medicine, St. Louis, United States.; Department of Neuroscience, Washington University School of Medicine, St. Louis, United States.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, United States., Siuda ER; Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, United States.; Washington University Pain Center, Washington University School of Medicine, St. Louis, United States.; Department of Neuroscience, Washington University School of Medicine, St. Louis, United States.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, United States., Bhatti DL; Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, United States.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, United States., Lawson LA; Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, United States., McElligott ZA; Department of Psychiatry, University of North Carolina, Chapel Hill, United States.; Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, United States., Stuber GD; Department of Psychiatry, University of North Carolina, Chapel Hill, United States.; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, United States.; Neuroscience Center, University of North Carolina, Chapel Hill, United States., Bruchas MR; Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, United States.; Washington University Pain Center, Washington University School of Medicine, St. Louis, United States.; Department of Neuroscience, Washington University School of Medicine, St. Louis, United States.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, United States.; Department of Biomedical Engineering, Washington University, St. Louis, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2017 Jul 14; Vol. 6. Date of Electronic Publication: 2017 Jul 14.
DOI:	10.7554/eLife.18247
Abstrakt:	Increased tonic activity of locus coeruleus noradrenergic (LC-NE) neurons induces anxiety-like and aversive behavior. While some information is known about the afferent circuitry that endogenously drives this neural activity and behavior, the downstream receptors and anatomical projections that mediate these acute risk aversive behavioral states via the LC-NE system remain unresolved. Here we use a combination of retrograde tracing, fast-scan cyclic voltammetry, electrophysiology, and in vivo optogenetics with localized pharmacology to identify neural substrates downstream of increased tonic LC-NE activity in mice. We demonstrate that photostimulation of LC-NE fibers in the BLA evokes norepinephrine release in the basolateral amygdala (BLA), alters BLA neuronal activity, conditions aversion, and increases anxiety-like behavior. Additionally, we report that β-adrenergic receptors mediate the anxiety-like phenotype of increased NE release in the BLA. These studies begin to illustrate how the complex efferent system of the LC-NE system selectively mediates behavior through distinct receptor and projection-selective mechanisms.
Databáze:	MEDLINE
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