Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.

Autor:	Wlodarska M; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Luo C; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA., Kolde R; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA., d'Hennezel E; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Annand JW; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Heim CE; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Krastel P; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Schmitt EK; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Omar AS; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Creasey EA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA., Garner AL; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mohammadi S; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., O'Connell DJ; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Abubucker S; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Arthur TD; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Franzosa EA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Huttenhower C; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Murphy LO; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Haiser HJ; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Vlamakis H; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Porter JA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Xavier RJ; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: xavier@molbio.mgh.harvard.edu.
Jazyk:	angličtina
Zdroj:	Cell host & microbe [Cell Host Microbe] 2017 Jul 12; Vol. 22 (1), pp. 25-37.e6.
DOI:	10.1016/j.chom.2017.06.007
Abstrakt:	Host factors in the intestine help select for bacteria that promote health. Certain commensals can utilize mucins as an energy source, thus promoting their colonization. However, health conditions such as inflammatory bowel disease (IBD) are associated with a reduced mucus layer, potentially leading to dysbiosis associated with this disease. We characterize the capability of commensal species to cleave and transport mucin-associated monosaccharides and identify several Clostridiales members that utilize intestinal mucins. One such mucin utilizer, Peptostreptococcus russellii, reduces susceptibility to epithelial injury in mice. Several Peptostreptococcus species contain a gene cluster enabling production of the tryptophan metabolite indoleacrylic acid (IA), which promotes intestinal epithelial barrier function and mitigates inflammatory responses. Furthermore, metagenomic analysis of human stool samples reveals that the genetic capability of microbes to utilize mucins and metabolize tryptophan is diminished in IBD patients. Our data suggest that stimulating IA production could promote anti-inflammatory responses and have therapeutic benefits. (Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu