Study of Visfatin Level in Type 1 Diabetic Children and Adolescents.

Autor:	El Samahi MH; Pediatrics Department and Pediatric Endocrinology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Ismail NA; Pediatrics Department, National Research Centre, Cairo, Egypt., Matter RM; Pediatrics Department and Pediatric Endocrinology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Selim A; Pediatrics Department, National Research Centre, Cairo, Egypt., Ibrahim AA; Clinical Pathology Department, National Research Centre, Cairo, Egypt., Nabih W; Pediatrics Department, National Research Centre, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	Open access Macedonian journal of medical sciences [Open Access Maced J Med Sci] 2017 Jun 11; Vol. 5 (3), pp. 299-304. Date of Electronic Publication: 2017 Jun 11 (Print Publication: 2017).
DOI:	10.3889/oamjms.2017.065
Abstrakt:	Background: Visfatin is an intracellular enzyme, known as nicotinamide phosphoribosyltransferase (Nampt) and pre-B-cell colony-enhancing factor (PBEF-1). It has insulin-mimetic effects and lowers plasma glucose levels. Aim: The aim of the work was to assess serum concentration of Visfatin in type 1 diabetic children and adolescents and study its relationships with duration of diabetes, body mass index (BMI), glycemic control, insulin dosage, lipid profile and microvascular complications. Material and Methods: Fifty children and adolescents with type 1 diabetes mellitus were recruited with 30 ages and gender-matched healthy subjects. They were subjected to history taking; anthropometric measurements and chronic diabetic complications were recorded if present. Laboratory analysis included urinary microalbumin, serum triglycerides, HDL, LDL, cholesterol, fasting blood glucose, glycosylated Hb (HbA1c) and serum visfatin which was measured with enzyme-linked immunosorbent assay. Results: Diabetic patients showed highly significant decrease in the level of visfatin compared to the control group (P = 0.0001). There was significant further decrease in visfatin level in diabetics with microalbuminuria (n = 13) compared to normoalbuminuric patients (n = 37) (P = 0.015). There was highly significant inverse correlation between visfatin level with age (r = -0.379, p = 0.007), BMI (r = -0.418, p = 0.003), waist circumference (r = -0.430, p = 0.002), hip circumference (r = -0.389, p = 0.005) and microalbuminuria (r = -0.323, p = 0.022). Conclusions: Type 1 diabetic children and adolescents had a significantly lower visfatin level compared to controls. A marked decrease in the level of visfatin was shown in patients with microalbuminuria with an inverse correlation with BMI suggesting an important role of visfatin in the pathogenesis of type 1 diabetics and type 1 diabetic nephropathy.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu