Are the TiO 2 NPs a "Trojan horse" for personal care products (PCPs) in the clam Ruditapes philippinarum?

Autor: Sendra M; Department of Ecology and Coastal Management, Institute of Marine Sciences of Andalusia (CSIC), Campus Río S. Pedro.11510, Puerto Real, Cádiz, 11510, Spain. Electronic address: marta.sendra@icman.csic.es., Pintado-Herrera MG; Physical Chemistry Department, Faculty of Marine and Environmental Sciences, University of Cadiz, Campus de Excelencia Internacional del Mar (CEI-MAR), Cádiz, 11510, Spain., Aguirre-Martínez GV; Andalusian Center for Marine Science and Technology (CACYTMAR), Campus Río S. Pedro.11510, Puerto Real, Cádiz, 11510, Spain; Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, 1110939, Iquique, Chile., Moreno-Garrido I; Department of Ecology and Coastal Management, Institute of Marine Sciences of Andalusia (CSIC), Campus Río S. Pedro.11510, Puerto Real, Cádiz, 11510, Spain., Martin-Díaz LM; Physical Chemistry Department, Faculty of Marine and Environmental Sciences, University of Cadiz, Campus de Excelencia Internacional del Mar (CEI-MAR), Cádiz, 11510, Spain; Andalusian Center for Marine Science and Technology (CACYTMAR), Campus Río S. Pedro.11510, Puerto Real, Cádiz, 11510, Spain., Lara-Martín PA; Physical Chemistry Department, Faculty of Marine and Environmental Sciences, University of Cadiz, Campus de Excelencia Internacional del Mar (CEI-MAR), Cádiz, 11510, Spain., J B; Department of Ecology and Coastal Management, Institute of Marine Sciences of Andalusia (CSIC), Campus Río S. Pedro.11510, Puerto Real, Cádiz, 11510, Spain.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2017 Oct; Vol. 185, pp. 192-204. Date of Electronic Publication: 2017 Jul 03.
DOI: 10.1016/j.chemosphere.2017.07.009
Abstrakt: In recent years, increasing quantities of personal care products (PCPs) are being released into the environment. However, data about bioaccumulation and toxicity are scarce; and extraction and analytical approaches are not well developed. In this work, the marine clam Ruditapes philippinarum, selected as model organism, has been employed to investigate bioaccumulation, antioxidant enzyme activities and DNA damage due to exposure to TiO 2 nanoparticles and bulk TiO 2 (inorganic compounds that are frequent components of PCPs, plastics, paints and coatings, foods and disinfectant water treatments). We have also studied the joint effect of both forms of inorganic TiO 2 combined with four organic compounds (mixture exposures) commonly used in PCPs: an antimicrobial (triclosan), a fragrance (OTNE) and two UV filters (benzophenone-3 and octocrylene). Bioaccumulation of the inorganic compound, TiO 2 , was almost immediate and constant over exposure time. With respect to the organic compounds in mixtures, they were mediated by TiO 2 and bioaccumulation is driven by reduced size of the particles. In fact, nanoparticles can be considered as a vector to organic compounds, such as triclosan and benzophenone-3. After a week of depuration, TiO 2 NPs and TiO 2 bulk in clams showed similar levels of concentration. Some organic compounds with bioactivity (Log K ow >3), like OTNE, showed low depuration after one week. The joint action of the organic compound mixture and either of the two forms of TiO 2 provoked changes in enzyme activity responses. However, for the mixtures, DNA damage was found only after the depuration period.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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