A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning.

Autor: Wang Q; Department of Mathematics, University of California, Irvine, United States.; Center for Complex Biological Systems, University of California, Irvine, United States., Oh JW; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States.; Department of Anatomy, School of Medicine, Kyungpook National University, Daegu, Korea.; Biomedical Research Institute, Kyungpook National University Hospital, Daegu, Korea.; Hair Transplantation Center, Kyungpook National University Hospital, Daegu, Korea., Lee HL; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Dhar A; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Peng T; Department of Mathematics, University of California, Irvine, United States., Ramos R; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Guerrero-Juarez CF; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Wang X; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Zhao R; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States.; Beijing Advanced Innovation Center for Food Nutrition and Human Health and State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China., Cao X; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States.; Department of Burn Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Le J; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Fuentes MA; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Jocoy SC; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Rossi AR; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Vu B; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Pham K; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Wang X; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States., Mali NM; Department of Anatomy, School of Medicine, Kyungpook National University, Daegu, Korea.; Biomedical Research Institute, Kyungpook National University Hospital, Daegu, Korea., Park JM; Department of Anatomy, School of Medicine, Kyungpook National University, Daegu, Korea.; Biomedical Research Institute, Kyungpook National University Hospital, Daegu, Korea., Choi JH; Department of Anatomy, School of Medicine, Kyungpook National University, Daegu, Korea.; Biomedical Research Institute, Kyungpook National University Hospital, Daegu, Korea., Lee H; Department of Anatomy, School of Medicine, Keimyung University, Daegu, Korea., Legrand JMD; UQ Diamantina Institute, Experimental Dermatology Group, Translational Research Institute, The University of Queensland, Brisbane, Australia., Kandyba E; Department of Pathology, Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angeles, United States., Kim JC; Hair Transplantation Center, Kyungpook National University Hospital, Daegu, Korea., Kim M; Hair Transplantation Center, Kyungpook National University Hospital, Daegu, Korea., Foley J; Department of Dermatology, Medical Sciences Program, Indiana University School of Medicine, Bloomington, United States., Yu Z; Beijing Advanced Innovation Center for Food Nutrition and Human Health and State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China., Kobielak K; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States.; Centre of New Technologies, CeNT, University of Warsaw, Warsaw, Poland., Andersen B; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States.; Departments of Medicine and Biological Chemistry, University of California, Irvine, United States., Khosrotehrani K; UQ Diamantina Institute, Experimental Dermatology Group, Translational Research Institute, The University of Queensland, Brisbane, Australia., Nie Q; Department of Mathematics, University of California, Irvine, United States.; Center for Complex Biological Systems, University of California, Irvine, United States.; Department of Developmental and Cell Biology, University of California, Irvine, United States., Plikus MV; Center for Complex Biological Systems, University of California, Irvine, United States.; Department of Developmental and Cell Biology, University of California, Irvine, United States.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, United States.
Jazyk: angličtina
Zdroj: ELife [Elife] 2017 Jul 11; Vol. 6. Date of Electronic Publication: 2017 Jul 11.
DOI: 10.7554/eLife.22772
Abstrakt: The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling, we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Interactions between fast-cycling chin and ventral HFs and slow-cycling dorsal HFs produce bilaterally symmetric patterns. Ear skin behaves as a hyper-refractory domain with HFs in extended rest phase. Such hyper-refractivity relates to high levels of BMP ligands and WNT antagonists, in part expressed by ear-specific cartilage and muscle. Hair growth stops at the boundaries with hyper-refractory ears and anatomically discontinuous eyelids, generating wave-breaking effects. We posit that similar mechanisms for coupled regeneration with dominant activator, hyper-refractory, and wave-breaker regions can operate in other actively renewing organs.
Databáze: MEDLINE