Adiponectin: Its role in obesity-associated colon and prostate cancers.

Autor: Muppala S; Department of Life Sciences, University of West Indies, St. Augustine, Trinidad and Tobago., Konduru SKP; Department of Medical Imaging, Sangre Grande General Hospital, Sangre Grande, Trinidad and Tobago., Merchant N; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA., Ramsoondar J; Department of Life Sciences, University of West Indies, St. Augustine, Trinidad and Tobago., Rampersad CK; Department of Life Sciences, University of West Indies, St. Augustine, Trinidad and Tobago., Rajitha B; Department of Biotechnology, Banasthali University, Banasthali, RJ, 304 022, India., Mukund V; Department of Biotechnology, Banasthali University, Banasthali, RJ, 304 022, India., Kancherla J; Department of Biotechnology, Banasthali University, Banasthali, RJ, 304 022, India., Hammond A; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA., Barik TK; Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, OR,760 007, India., Mannarapu M; Department of Biotechnology, Dravidian University, Kuppam, AP, 517 426, India., Alam A; Department of Biotechnology, Banasthali University, Banasthali, RJ, 304 022, India; Department of Bioscience & Biotechnology, Banasthali University, Banasthali, Raj, 304 022, India., Basha R; Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA., Bramhachari PV; Department of Biotechnology, Krishna University, Machilipatnam, AP, 521 001, India., Verma D; Department of Biology, Valencia College, Kissimmee, FL, 34744, USA., Sushma PS; Department of Biotechnology, Dr. NTR University of Health Sciences, Vijayawada, AP 520 008, India., Pattnaik S; Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, OR,760 007, India., Nagaraju GP; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA; Department of Biotechnology, Berhampur University, Bhanjavihar, Berhampur, OR,760 007, India. Electronic address: pganji@emory.edu.
Jazyk: angličtina
Zdroj: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2017 Aug; Vol. 116, pp. 125-133. Date of Electronic Publication: 2017 Jun 09.
DOI: 10.1016/j.critrevonc.2017.06.003
Abstrakt: Adipose tissue synthesizes many proteins and hormones collectively called adipokines, which are linked to a number of diseases, including cancer. Low levels of adiponectin are reported to be a risk factor for obesity-related cancers including colorectal and prostate cancers. Accordingly, obesity/lifestyle-related diseases, including certain cancers, may be treated by developing drugs that act specifically on adiponectin levels in circulation. Adiponectin may also serve as a clinical biomarker in obesity-related diseases. Adiponectin-based therapies are known to inhibit cancer advancement and thus may provide a therapeutic approach to delay cancer progression. Better understanding of the function of adiponectin is of great significance in the fight against cancer. This timely review is concentrated on the role of adiponectin and the impact of obesity on the development of cancers, especially colorectal and prostate cancers.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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