Systemic effects of H 2 S inhalation at human equivalent dose of pathologic halitosis on rats.
Autor: | Yalçın Yeler D; a Department of Oral and Maxillofacial Radiology, Faculty of Dentistry , Cumhuriyet University , Sivas , Türkiye., Aydin M; b Private Practice , Adana , Türkiye., Gül M; c Department of Histology and Embryology, Faculty of Medicine , Inönü University , Malatya , Türkiye., Hocaoğlu T; d Department of Oral and Maxillofacial Surgery, Faculty of Dentistry , Cumhuriyet University , Sivas , Türkiye., Özdemir H; e Department of Periodontology, Faculty of Dentistry , Osmangazi University , Eskisehir , Türkiye., Koraltan M; a Department of Oral and Maxillofacial Radiology, Faculty of Dentistry , Cumhuriyet University , Sivas , Türkiye. |
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Jazyk: | angličtina |
Zdroj: | Acta odontologica Scandinavica [Acta Odontol Scand] 2017 Oct; Vol. 75 (7), pp. 517-523. Date of Electronic Publication: 2017 Jul 11. |
DOI: | 10.1080/00016357.2017.1350992 |
Abstrakt: | Objectives: Halitosis is composed by hundreds of toxic gases. It is still not clear whether halitosis gases self-inhaled by halitosis patients cause side effects. The aim of the study was to investigate the effect of H Materials and Methods: The threshold level of pathologic halitosis perceived by humans at 250 ppb of H Results: While aspartate transaminase, creatine kinase-MB and lactate dehydrogenase levels were found to be significantly elevated, carbondioxide and alkaline phosphatase were decreased in experimental rats. Other blood parameters were not changed significantly. Experimental rats lost weight and became anxious. Histopathological examination showed mononuclear inflammatory cell invasion in the portal areas, nuclear glycogen vacuoles in the parenchymal area, single-cell necrosis in a few foci, clear expansion in the central hepatic vein and sinusoids, hyperplasia in Kupffer cells and potential fibrous tissue expansion in the portal areas in the experimental rats. However, no considerable histologic damage was observed in the brain and kidney specimens. Conclusions: It can be concluded that H |
Databáze: | MEDLINE |
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