Autoamputation and Polyneuropathy in Mixed Connective Tissue Disorder: A Case Report.

Autor:	Naqvi S; Jinnah Postgraduate Medical Centre, Jinnah Sindh Medical University (SMC)., Talib V; Accident & Emergency, Jinnah Postgraduate Medical Center Karachi Pakistan., Aijaz R; Internal Medicine, Jinnah Postgraduate Medical Center Karachi Pakistan., Ali Z; Jinnah Postgrduate Medical Centre, Jinnah Sindh Medical University (SMC)., Bashir S; Medicine Unit 7, Jinnah Postgraduate Medical Center Karachi Pakistan., Ahmad SM; Medicine, Jinnah Postgraduate Medical Centre Karachi Pakistan., Naveed S; Department of Medicine, Jinnah Postgraduate Medical Center Karachi Pakistan.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2017 Jun 05; Vol. 9 (6), pp. e1313. Date of Electronic Publication: 2017 Jun 05.
DOI:	10.7759/cureus.1313
Abstrakt:	Mixed connective tissue disorder (MCTD) is a multisystem disease with overlapping features of other autoimmune diseases, such as systemic lupus erythematosus (SLE), myositis, rheumatoid arthritis, and scleroderma. MCTD presents with a distinctive antibody in serum known as U1-ribonucleoprotein (RNP). MCTD is quite rare as compared to other connective tissue disorders like SLE, systemic sclerosis, dermatomyositis, and polymyositis. We describe a case of MCTD in a young Asian female of 30 year old. This case highlights rare co-existence of polyneuropathy and autoamputation in MCTD disorder. Trigeminal neuralgia and cranial nerve involvements have been previously reported in MCTD but the findings of polyneuropathy and autoamputation are extremely rare. Competing Interests: The authors have declared that no competing interests exist.
Databáze:	MEDLINE
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