Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age.
| Autor: | Alif SM; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Dharmage SC; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Murdoch Childrens Research Institute, Melbourne, Victoria, Australia., Benke G; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Dennekamp M; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.; Graduate Entry Medical School, University of Limerick, Limerick, Ireland., Burgess JA; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Perret JL; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Respiratory and Sleep Medicine, Austin Hospital, Melbourne, Victoria, Australia., Lodge CJ; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Morrison S; Department of Medicine, University of Queensland, Brisbane, Queensland, Australia., Johns DP; School of Medicine, University of Tasmania, Hobart, Tasmania, Australia., Giles GG; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia., Gurrin LC; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Murdoch Childrens Research Institute, Melbourne, Victoria, Australia., Thomas PS; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia., Hopper JL; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Wood-Baker R; School of Medicine, University of Tasmania, Hobart, Tasmania, Australia., Thompson BR; Allergy Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, Australia., Feather IH; Gold Coast University Hospital, Southport, Queensland, Australia.; Bond University, Robina, Queensland, Australia., Vermeulen R; Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Kromhout H; Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Walters EH; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.; School of Medicine, University of Tasmania, Hobart, Tasmania, Australia., Abramson MJ; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Matheson MC; Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Murdoch Childrens Research Institute, Melbourne, Victoria, Australia. |
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| Jazyk: | angličtina |
| Zdroj: | Thorax [Thorax] 2017 Nov; Vol. 72 (11), pp. 990-997. Date of Electronic Publication: 2017 Jul 07. |
| DOI: | 10.1136/thoraxjnl-2016-209665 |
| Abstrakt: | Rationale: Population-based studies have found evidence of a relationship between occupational exposures and Chronic Obstructive Pulmonary Disease (COPD), but these studies are limited by the use of prebronchodilator spirometry. Establishing this link using postbronchodilator is critical, because occupational exposures are a modifiable risk factor for COPD. Objectives: To investigate the associations between occupational exposures and fixed airflow obstruction using postbronchodilator spirometry. Methods: One thousand three hundred and thirty-five participants were included from 2002 to 2008 follow-up of the Tasmanian Longitudinal Health Study (TAHS). Spirometry was performed and lifetime work history calendars were used to collect occupational history. ALOHA plus Job Exposure Matrix was used to assign occupational exposure, and defined as ever exposed and cumulative exposure unit (EU)-years. Fixed airflow obstruction was defined by postbronchodilator FEV Results: Ever exposure to biological dust (relative risk (RR)=1.58, 95% CI 1.01 to 2.48), pesticides (RR=1.74,95% CI 1.00 to 3.07) and herbicides (RR=2.09,95% CI 1.18 to 3.70) were associated with fixed airflow obstruction. Cumulative EU-years to all pesticides (RR=1.11,95% CI 1.00 to 1.25) and herbicides (RR=1.15,95% CI 1.00 to 1.32) were also associated with fixed airflow obstruction. In addition, all pesticides exposure was consistently associated with chronic bronchitis and symptoms that are consistent with airflow obstruction. Ever exposure to mineral dust, gases/fumes and vapours, gases, dust or fumes were only associated with fixed airflow obstruction in non-asthmatics only. Conclusions: Pesticides and herbicides exposures were associated with fixed airflow obstruction and chronic bronchitis. Biological dust exposure was also associated with fixed airflow obstruction in non-asthmatics. Minimising occupational exposure to these agents may help to reduce the burden of COPD. Competing Interests: Competing interests: None declared. (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.) |
| Databáze: | MEDLINE |
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