| Autor: |
Secor JW, Speeg KV Jr, Meredith CG, Johnson RF, Snowdy P, Schenker S |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of clinical pharmacology [Br J Clin Pharmacol] 1985 Dec; Vol. 20 (6), pp. 710-3. |
| DOI: |
10.1111/j.1365-2125.1985.tb05136.x |
| Abstrakt: |
The effect of nizatidine, a new H2-receptor antagonist, on the hepatic metabolism of three probe drugs was studied in normal volunteers. The drugs studied were chlordiazepoxide and theophylline which are metabolized in part by N-demethylation by the hepatic microsomal cytochrome P-450 system and lorazepam which is conjugated to lorazepam glucuronide. A 7 day course of nizatidine did not interfere with the disposition of any of these therapeutic agents in man. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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